Effect of oral sucrose on blood pressure in the spontaneously hypertensive rat

James B. Young; Lewis Landsberg

doi:10.1016/0026-0495(81)90173-6

Effect of oral sucrose on blood pressure in the spontaneously hypertensive rat

James B. Young^*, Lewis Landsberg

^*Corresponding author for this work

Medicine, Endocrinology Division

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

In the spontaneously hypertensive rat (SHR) increased carbohydrate intake without alteration in sodium intake is associated with elevated blood pressure. One week of feeding sucrose-supplemented chow increased blood pressure an average of 14mm Hg (9%) in three separate groups of SHR, but did not affect blood pressure in normotensive rats of the same strain (Wistar-Kyoto-WKY). Fat supplementation (isocaloric to sucrose) was without effect on blood pressure in SHR. These data are consistent with the hypothesis that diet-induced increases in sympathetic activity may elevate blood pressure in susceptible animals.

Original language	English (US)
Pages (from-to)	421-424
Number of pages	4
Journal	Metabolism
Volume	30
Issue number	5
DOIs	https://doi.org/10.1016/0026-0495(81)90173-6
State	Published - May 1981

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0026-0495(81)90173-6

Cite this

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title = "Effect of oral sucrose on blood pressure in the spontaneously hypertensive rat",

abstract = "In the spontaneously hypertensive rat (SHR) increased carbohydrate intake without alteration in sodium intake is associated with elevated blood pressure. One week of feeding sucrose-supplemented chow increased blood pressure an average of 14mm Hg (9%) in three separate groups of SHR, but did not affect blood pressure in normotensive rats of the same strain (Wistar-Kyoto-WKY). Fat supplementation (isocaloric to sucrose) was without effect on blood pressure in SHR. These data are consistent with the hypothesis that diet-induced increases in sympathetic activity may elevate blood pressure in susceptible animals.",

author = "Young, {James B.} and Lewis Landsberg",

note = "Funding Information: From lhe Charles A. Dana Research Institute and the Harvard-Thorndike Laboratory, Department oj{\textquoteleft} Medicine, Berh Israel Hospital and Harvard Medical School, Boston. Massachuserts. Supported in part by USPHS Grants HL 24084 and AM 20378. Received for publication May 16. 1980. Address reprint requests to Dr. James B. Young. Department of Medicine, Beth Israel Hospital. 330 Brookline Avenue, Boston.",

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doi = "10.1016/0026-0495(81)90173-6",

language = "English (US)",

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T1 - Effect of oral sucrose on blood pressure in the spontaneously hypertensive rat

AU - Young, James B.

AU - Landsberg, Lewis

N1 - Funding Information: From lhe Charles A. Dana Research Institute and the Harvard-Thorndike Laboratory, Department oj‘ Medicine, Berh Israel Hospital and Harvard Medical School, Boston. Massachuserts. Supported in part by USPHS Grants HL 24084 and AM 20378. Received for publication May 16. 1980. Address reprint requests to Dr. James B. Young. Department of Medicine, Beth Israel Hospital. 330 Brookline Avenue, Boston.

PY - 1981/5

Y1 - 1981/5

N2 - In the spontaneously hypertensive rat (SHR) increased carbohydrate intake without alteration in sodium intake is associated with elevated blood pressure. One week of feeding sucrose-supplemented chow increased blood pressure an average of 14mm Hg (9%) in three separate groups of SHR, but did not affect blood pressure in normotensive rats of the same strain (Wistar-Kyoto-WKY). Fat supplementation (isocaloric to sucrose) was without effect on blood pressure in SHR. These data are consistent with the hypothesis that diet-induced increases in sympathetic activity may elevate blood pressure in susceptible animals.

AB - In the spontaneously hypertensive rat (SHR) increased carbohydrate intake without alteration in sodium intake is associated with elevated blood pressure. One week of feeding sucrose-supplemented chow increased blood pressure an average of 14mm Hg (9%) in three separate groups of SHR, but did not affect blood pressure in normotensive rats of the same strain (Wistar-Kyoto-WKY). Fat supplementation (isocaloric to sucrose) was without effect on blood pressure in SHR. These data are consistent with the hypothesis that diet-induced increases in sympathetic activity may elevate blood pressure in susceptible animals.

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Effect of oral sucrose on blood pressure in the spontaneously hypertensive rat

Abstract

ASJC Scopus subject areas

UN SDGs

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