Effect of oral sucrose on blood pressure in the spontaneously hypertensive rat

James B. Young*, Lewis Landsberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

In the spontaneously hypertensive rat (SHR) increased carbohydrate intake without alteration in sodium intake is associated with elevated blood pressure. One week of feeding sucrose-supplemented chow increased blood pressure an average of 14mm Hg (9%) in three separate groups of SHR, but did not affect blood pressure in normotensive rats of the same strain (Wistar-Kyoto-WKY). Fat supplementation (isocaloric to sucrose) was without effect on blood pressure in SHR. These data are consistent with the hypothesis that diet-induced increases in sympathetic activity may elevate blood pressure in susceptible animals.

Original languageEnglish (US)
Pages (from-to)421-424
Number of pages4
JournalMetabolism
Volume30
Issue number5
DOIs
StatePublished - May 1981

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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