Abstract
In the spontaneously hypertensive rat (SHR) increased carbohydrate intake without alteration in sodium intake is associated with elevated blood pressure. One week of feeding sucrose-supplemented chow increased blood pressure an average of 14mm Hg (9%) in three separate groups of SHR, but did not affect blood pressure in normotensive rats of the same strain (Wistar-Kyoto-WKY). Fat supplementation (isocaloric to sucrose) was without effect on blood pressure in SHR. These data are consistent with the hypothesis that diet-induced increases in sympathetic activity may elevate blood pressure in susceptible animals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 421-424 |
| Number of pages | 4 |
| Journal | Metabolism |
| Volume | 30 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1981 |
Funding
From lhe Charles A. Dana Research Institute and the Harvard-Thorndike Laboratory, Department oj‘ Medicine, Berh Israel Hospital and Harvard Medical School, Boston. Massachuserts. Supported in part by USPHS Grants HL 24084 and AM 20378. Received for publication May 16. 1980. Address reprint requests to Dr. James B. Young. Department of Medicine, Beth Israel Hospital. 330 Brookline Avenue, Boston.
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism