Effect of Perphenazine Treatment of Rats on Serum Ovarian and Adrenal Steroids

Robert T. Chatterton, Janet Chien, Dean A. Ward

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Abstract

A comparison of the concentration of steroids in peripheral serum was made between normal rats in the third day of diestrus and rats injected subcutaneously for 3 days with 5 mg/kg body wt/day perphenazine. Progesterone levels were most markedly altered. When perphenazine treatment was begun on the afternoon following ovulation, the average progesterone level was increased 17-fold over that of untreated control rats; when treatment was begun on the afternoon preceding ovulation, the concentration of progesterone was increased only ten-fold. 20α-Hydroxypregn-4-en-3-one was only slightly decreased by the treatment. Irrespective of the day treatment was initiated, corticosterone was increased (threefold) and estradiol-17β was decreased (sixfold) by perphenazine administration. The results are discussed in relation to the known effects of perphenazine administration on prolactin secretion.

Original languageEnglish (US)
Pages (from-to)874-878
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume145
Issue number3
DOIs
Publication statusPublished - Jan 1 1974

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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