@article{8d61f2d7f38245d89172d93590723972,
title = "Effect of Physical Activity versus Health Education on Physical Function, Grip Strength and Mobility",
abstract = "Background: Physical activity (PA) reduces the rate of mobility disability, compared with health education (HE), in at risk older adults. It is important to understand aspects of performance contributing to this benefit. Objective: To evaluate intervention effects on tertiary physical performance outcomes. Design: The Lifestyle Interventions and Independence for Elders (LIFE) was a multi-centered, single-blind randomized trial of older adults. Setting: Eight field centers throughout the United States. Participants: 1635 adults aged 78.9 ± 5.2 years, 67.2% women at risk for mobility disability (Short Physical Performance Battery [SPPB] <10). Interventions: Moderate PA including walking, resistance and balance training compared with HE consisting of topics relevant to older adults. Outcomes: Grip strength, SPPB score and its components (balance, 4 m gait speed, and chair-stands), as well as 400 m walking speed. Results: Total SPPB score was higher in PA versus HE across all follow-up times (overall P =.04) as was the chair-stand component (overall P <.001). No intervention effects were observed for balance (overall P =.12), 4 m gait speed (overall P =.78), or grip strength (overall P =.62). However, 400 m walking speed was faster in PA versus HE group (overall P =<.001). In separate models, 29% of the rate reduction of major mobility disability in the PA versus HE group was explained by change in SPPB score, while 39% was explained by change in the chair stand component. Conclusion: Lower extremity performance (SPPB) was significantly higher in the PA compared with HE group. Changes in chair-stand score explained a considerable portion of the effect of PA on the reduction of major mobility disability–consistent with the idea that preserving muscle strength/power may be important for the prevention of major mobility disability.",
keywords = "gait speed, physical activity, physical function, randomized clinical trial",
author = "{the LIFE Study Group} and Santanasto, {Adam J.} and Glynn, {Nancy W.} and Lovato, {Laura C.} and Blair, {Steven N.} and Fielding, {Roger A.} and Gill, {Thomas M.} and Guralnik, {Jack M.} and Hsu, {Fang Chi} and King, {Abby C.} and Strotmeyer, {Elsa S.} and Manini, {Todd M.} and Marsh, {Anthony P.} and McDermott, {Mary M.} and Goodpaster, {Bret H.} and Marco Pahor and Newman, {Anne B.}",
note = "Funding Information: Conflicts of Interest: Dr. Roger Fielding (Tufts University) is partially supported by the U.S. Department of Agriculture, under agreement No. 58-1950-0-014. Any opinions, findings, conclusion, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the view of the U.S. Department of Agriculture. All other authors have no conflicts to report. Author contributions: NWG, SNB, RAF, TMG, JMG, ACK, ESS, TMM, APM, MMM, BHG, MP and ABN designed the research; all authors participated in interpretation of the data; LCL and FCH analyzed the data; AJS and ABN drafted the manuscript; all authors gave critical revisions of the manuscript for important intellectual content; NWG, SNB, RAF, TMG, JMG, ACK, TMM, APM, MMM, BHG, MP and ABN obtained funding; LCL and FCH performed statistical analyses; and all authors gave final approval of the manuscript. Sponsor's Role and Funding Sources for the LIFE Study: The following funded design, methods, subject recruitment, data collection, analysis and/or preparation of paper: National Institutes of Health/National Institute on Aging Cooperative Agreement #UO1 AG22376 and a supplement from the National Heart, Lung and Blood Institute 3U01AG022376-05A2S, and sponsored in part by the Intramural Research Program, National Institute on Aging, NIH. The research is partially supported by the Claude D. Pepper Older Americans Independence Centers at the University of Florida (1P30AG028740), Wake Forest University (1P30AG21332), Tufts University (1P30AG031679), University of Pittsburgh (P30AG024827), and Yale University (P30AG021342) and the NIH/NCRR CTSA at Stanford University (UL1 RR025744), Tufts University is also supported by the Boston Rehabilitation Outcomes Center (1R24HD065688-01A1). Authors are also partially supported by the following: Dr. Thomas Gill (Yale University) is the recipient of an Academic Leadership Award (K07AG3587) from the National Institute on Aging.",
year = "2017",
month = jul,
doi = "10.1111/jgs.14804",
language = "English (US)",
volume = "65",
pages = "1427--1433",
journal = "Journal of the American Geriatrics Society",
issn = "0002-8614",
publisher = "Wiley-Blackwell",
number = "7",
}