The influence of layer thickness and ply interdispersion was investigated on the failure characteristics of multidirectional laminates. The composite material investigated was a high strength carbon fiber composite with a toughened epoxy matrix (IM7/8552). The basic unidirectional material was fully characterized in a previous study under static and dynamic loading conditions. In this study the investigation was extended to angle-ply laminates with varying layer thickness while including the effects of residual stresses. Intralaminar and interlaminar failure mechanisms were observed and found to be strongly related to the layer thickness for the same layup. For thin layer thicknesses failure modes included fiber breaks resulting in higher ultimate strengths. For thicker layers consisting of multiple stacked parallel plies, more matrix dominated intralaminar and interlaminar failures were observed resulting in lower ultimate strengths. This trend reaches a lower limiting plateau as the layer thickness increases. Failure modes and ultimate strengths were further investigated as a function of strain rate. All results were evaluated by the recently developed Northwestern (NU) failure theory.