Effect of prefrontal cortex damage on resolving lexical ambiguity in text

Carol Frattali; Rebecca Hanna; Anita Shukla McGinty; Lynn Gerber; Robert Wesley; Jordan Grafman; Carl Coelho

doi:10.1016/j.bandl.2006.09.007

Effect of prefrontal cortex damage on resolving lexical ambiguity in text

Carol Frattali, Rebecca Hanna, Anita Shukla McGinty, Lynn Gerber, Robert Wesley, Jordan Grafman^*, Carl Coelho

^*Corresponding author for this work

Physical Medicine and Rehabilitation

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The function of suppression of context-inappropriate meanings during lexical ambiguity resolution was examined in 25 adults with prefrontal cortex damage (PFCD) localized to the left (N = 8), right (N = 6), or bilaterally (N = 11); and 21 matched Controls. Results revealed unexpected inverse patterns of suppression between PFCD and Control groups, with measures suggesting decreased interference across time in the PFCD group and increased interference in the Control group. The PFCD group, however, had significantly lower accuracy rates for the context-inappropriate condition. Results suggest a loss of the control aspects of inhibitory processes in lexical ambiguity resolution following PFCD. An aging effect on suppression function is also suggested.

Original language	English (US)
Pages (from-to)	99-113
Number of pages	15
Journal	Brain and Language
Volume	102
Issue number	1
DOIs	https://doi.org/10.1016/j.bandl.2006.09.007
State	Published - Jul 2007

Keywords

Aging effects
Inhibitory control
Lexical ambiguity
Prefrontal cortex damage
Suppression
Text comprehension

ASJC Scopus subject areas

Language and Linguistics
Experimental and Cognitive Psychology
Linguistics and Language
Cognitive Neuroscience
Speech and Hearing

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10.1016/j.bandl.2006.09.007

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title = "Effect of prefrontal cortex damage on resolving lexical ambiguity in text",

abstract = "The function of suppression of context-inappropriate meanings during lexical ambiguity resolution was examined in 25 adults with prefrontal cortex damage (PFCD) localized to the left (N = 8), right (N = 6), or bilaterally (N = 11); and 21 matched Controls. Results revealed unexpected inverse patterns of suppression between PFCD and Control groups, with measures suggesting decreased interference across time in the PFCD group and increased interference in the Control group. The PFCD group, however, had significantly lower accuracy rates for the context-inappropriate condition. Results suggest a loss of the control aspects of inhibitory processes in lexical ambiguity resolution following PFCD. An aging effect on suppression function is also suggested.",

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AU - Frattali, Carol

AU - Hanna, Rebecca

AU - McGinty, Anita Shukla

AU - Gerber, Lynn

AU - Wesley, Robert

AU - Grafman, Jordan

AU - Coelho, Carl

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Effect of prefrontal cortex damage on resolving lexical ambiguity in text

Abstract

Keywords

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