Effect of prostaglandin D2 and I2 on the airways of rhesus monkeys

Roy Patterson*, Kathleen E. Harris, Paul Allen Greenberger

*Corresponding author for this work

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Prostaglandin (PG) D2 and PGI2 were evaluated to determine their effect on pulmonary function parameters when aerosolized in anesthetized rhesus monkeys. PGD2 resulted in an increase in frequency (f) and pulmonary resistance (RL) and a decrease in peak expiratory flow rate (PEFR), tidal volume (VT), and dynamic compliance (Cdyn), with the major effect on RL. PGI2 primarily effected an increase in f and a decrease in PEFR and VT. PGI2 had a variable effect, generally a decrease, on RL. The metabolite of PGI2, 6-keto-PGF, had no effect on the rhesus airway. PGF responses were similar to PGD2 except that the PGF produced a less strikingly consistent increase in RL. When PGI2 and PGD2 were aerosolized simultaneously, they simulated previously described antigen responses. Further, PGI2 plus PGD2 produced an airway response at 1 10 the concentration of either agent alone.

Original languageEnglish (US)
Pages (from-to)269-273
Number of pages5
JournalThe Journal of Allergy and Clinical Immunology
Volume65
Issue number4
DOIs
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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