Effect of prostaglandin D2 and I2 on the airways of rhesus monkeys

Roy Patterson; Kathleen E. Harris; Paul Allen Greenberger

doi:10.1016/0091-6749(80)90154-2

Effect of prostaglandin D₂ and I₂ on the airways of rhesus monkeys

Roy Patterson^*, Kathleen E. Harris, Paul Allen Greenberger

^*Corresponding author for this work

Medicine, Allergy Division

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Prostaglandin (PG) D₂ and PGI₂ were evaluated to determine their effect on pulmonary function parameters when aerosolized in anesthetized rhesus monkeys. PGD₂ resulted in an increase in frequency (f) and pulmonary resistance (R_L) and a decrease in peak expiratory flow rate (PEFR), tidal volume (V_T), and dynamic compliance (Cdyn), with the major effect on R_L. PGI₂ primarily effected an increase in f and a decrease in PEFR and V_T. PGI₂ had a variable effect, generally a decrease, on R_L. The metabolite of PGI₂, 6-keto-PGF_1α, had no effect on the rhesus airway. PGF_2α responses were similar to PGD₂ except that the PGF_2α produced a less strikingly consistent increase in R_L. When PGI₂ and PGD₂ were aerosolized simultaneously, they simulated previously described antigen responses. Further, PGI₂ plus PGD₂ produced an airway response at 1 10 the concentration of either agent alone.

Original language	English (US)
Pages (from-to)	269-273
Number of pages	5
Journal	The Journal of Allergy and Clinical Immunology
Volume	65
Issue number	4
DOIs	https://doi.org/10.1016/0091-6749(80)90154-2
State	Published - Jan 1 1980

Funding

From the Section of Allergy-Immunology, Department of e, Northwestern University Medical School. SU by U.S. Public Health Service Grant AI 11759 and the Erttest S. Barley Grant. Receded for publication May 21, 1979. AcceaU;d for publication Aug. 2, 1979. Rep&t xequests to: Roy Patterson, M.D., Allergy-Immunology !&km, Department of Medicine, Northwestern University Medical School, 303 E. Chicago Ave., Chicago, IL 60611.

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1016/0091-6749(80)90154-2

Cite this

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title = "Effect of prostaglandin D2 and I2 on the airways of rhesus monkeys",

abstract = "Prostaglandin (PG) D2 and PGI2 were evaluated to determine their effect on pulmonary function parameters when aerosolized in anesthetized rhesus monkeys. PGD2 resulted in an increase in frequency (f) and pulmonary resistance (RL) and a decrease in peak expiratory flow rate (PEFR), tidal volume (VT), and dynamic compliance (Cdyn), with the major effect on RL. PGI2 primarily effected an increase in f and a decrease in PEFR and VT. PGI2 had a variable effect, generally a decrease, on RL. The metabolite of PGI2, 6-keto-PGF1α, had no effect on the rhesus airway. PGF2α responses were similar to PGD2 except that the PGF2α produced a less strikingly consistent increase in RL. When PGI2 and PGD2 were aerosolized simultaneously, they simulated previously described antigen responses. Further, PGI2 plus PGD2 produced an airway response at 1 10 the concentration of either agent alone.",

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N2 - Prostaglandin (PG) D2 and PGI2 were evaluated to determine their effect on pulmonary function parameters when aerosolized in anesthetized rhesus monkeys. PGD2 resulted in an increase in frequency (f) and pulmonary resistance (RL) and a decrease in peak expiratory flow rate (PEFR), tidal volume (VT), and dynamic compliance (Cdyn), with the major effect on RL. PGI2 primarily effected an increase in f and a decrease in PEFR and VT. PGI2 had a variable effect, generally a decrease, on RL. The metabolite of PGI2, 6-keto-PGF1α, had no effect on the rhesus airway. PGF2α responses were similar to PGD2 except that the PGF2α produced a less strikingly consistent increase in RL. When PGI2 and PGD2 were aerosolized simultaneously, they simulated previously described antigen responses. Further, PGI2 plus PGD2 produced an airway response at 1 10 the concentration of either agent alone.

AB - Prostaglandin (PG) D2 and PGI2 were evaluated to determine their effect on pulmonary function parameters when aerosolized in anesthetized rhesus monkeys. PGD2 resulted in an increase in frequency (f) and pulmonary resistance (RL) and a decrease in peak expiratory flow rate (PEFR), tidal volume (VT), and dynamic compliance (Cdyn), with the major effect on RL. PGI2 primarily effected an increase in f and a decrease in PEFR and VT. PGI2 had a variable effect, generally a decrease, on RL. The metabolite of PGI2, 6-keto-PGF1α, had no effect on the rhesus airway. PGF2α responses were similar to PGD2 except that the PGF2α produced a less strikingly consistent increase in RL. When PGI2 and PGD2 were aerosolized simultaneously, they simulated previously described antigen responses. Further, PGI2 plus PGD2 produced an airway response at 1 10 the concentration of either agent alone.

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