Effect of sodium salicylate on hamster cells in vitro

M. Rubenstein; D. Giacomoni; L. M. Pachman

doi:10.1002/jps.2600650537

Effect of sodium salicylate on hamster cells in vitro

M. Rubenstein, D. Giacomoni, L. M. Pachman^*

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Doses of sodium salicylate greater than 100 μg/ml increased the generation time of baby hamster kidney (BHK 21) cells in culture from 16 to 35 hr. Exposure to similar doses of salicylate for 18–44 hr resulted in a marked reduction of RNA synthesis. The species of RNA synthesized in the presence of sodium salicylate appeared to be similar to those synthesized by normal cells in the absence of sodium salicylate. Sodium salicylate did not alter the oxidative phosphorylation of BHK cells.

Original language	English (US)
Pages (from-to)	756-758
Number of pages	3
Journal	Journal of Pharmaceutical Sciences
Volume	65
Issue number	5
DOIs	https://doi.org/10.1002/jps.2600650537
State	Published - May 1976

Keywords

Analgesics—sodium salicylate, effect on hamster kidney cells in culture, generation time, RNA synthesis
Cell culture—hamster kidney cells, effect of sodium salicylate on generation and RNA synthesis
RNA synthesis—hamster kidney cells in culture, effect of sodium salicylate
Sodium salicylate—effect on hamster kidney cells in culture, generation time, RNA synthesis

ASJC Scopus subject areas

Pharmaceutical Science

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10.1002/jps.2600650537

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title = "Effect of sodium salicylate on hamster cells in vitro",

abstract = "Doses of sodium salicylate greater than 100 μg/ml increased the generation time of baby hamster kidney (BHK 21) cells in culture from 16 to 35 hr. Exposure to similar doses of salicylate for 18–44 hr resulted in a marked reduction of RNA synthesis. The species of RNA synthesized in the presence of sodium salicylate appeared to be similar to those synthesized by normal cells in the absence of sodium salicylate. Sodium salicylate did not alter the oxidative phosphorylation of BHK cells.",

keywords = "Analgesics—sodium salicylate, effect on hamster kidney cells in culture, generation time, RNA synthesis, Cell culture—hamster kidney cells, effect of sodium salicylate on generation and RNA synthesis, RNA synthesis—hamster kidney cells in culture, effect of sodium salicylate, Sodium salicylate—effect on hamster kidney cells in culture, generation time, RNA synthesis",

author = "M. Rubenstein and D. Giacomoni and Pachman, {L. M.}",

note = "Funding Information: Received September 3, 1974, from the *Department of Microbiology, University of Illinois at the Medical Center, Chicago, IL 60612 and the fDepartment of Pediatrics, Northwestern Uniuer-sity, Children{\textquoteright}s Memorial Hospital, Chicago, IL 6061if Accepted for publication July 14,1975. Supported in part by a grant from the Illinois Chapter of the Arthritis Foundation, the Apfelbaum Foundation, and the Leukemia Research Foundation, Chicago, Ill. The authors thank Sandra M. Baldwin for technical assistance. 8 Supported by U.S. Public Health Service Grant PHS A1 00335 in partial fulfillment of the Doctor of Philosophy degree requirements at the University of Illinois at the Medical Center. To whom inquiries should be directed.",

year = "1976",

month = may,

doi = "10.1002/jps.2600650537",

language = "English (US)",

volume = "65",

pages = "756--758",

journal = "Journal of Pharmaceutical Sciences",

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publisher = "Elsevier B.V.",

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T1 - Effect of sodium salicylate on hamster cells in vitro

AU - Rubenstein, M.

AU - Giacomoni, D.

AU - Pachman, L. M.

N1 - Funding Information: Received September 3, 1974, from the *Department of Microbiology, University of Illinois at the Medical Center, Chicago, IL 60612 and the fDepartment of Pediatrics, Northwestern Uniuer-sity, Children’s Memorial Hospital, Chicago, IL 6061if Accepted for publication July 14,1975. Supported in part by a grant from the Illinois Chapter of the Arthritis Foundation, the Apfelbaum Foundation, and the Leukemia Research Foundation, Chicago, Ill. The authors thank Sandra M. Baldwin for technical assistance. 8 Supported by U.S. Public Health Service Grant PHS A1 00335 in partial fulfillment of the Doctor of Philosophy degree requirements at the University of Illinois at the Medical Center. To whom inquiries should be directed.

PY - 1976/5

Y1 - 1976/5

N2 - Doses of sodium salicylate greater than 100 μg/ml increased the generation time of baby hamster kidney (BHK 21) cells in culture from 16 to 35 hr. Exposure to similar doses of salicylate for 18–44 hr resulted in a marked reduction of RNA synthesis. The species of RNA synthesized in the presence of sodium salicylate appeared to be similar to those synthesized by normal cells in the absence of sodium salicylate. Sodium salicylate did not alter the oxidative phosphorylation of BHK cells.

AB - Doses of sodium salicylate greater than 100 μg/ml increased the generation time of baby hamster kidney (BHK 21) cells in culture from 16 to 35 hr. Exposure to similar doses of salicylate for 18–44 hr resulted in a marked reduction of RNA synthesis. The species of RNA synthesized in the presence of sodium salicylate appeared to be similar to those synthesized by normal cells in the absence of sodium salicylate. Sodium salicylate did not alter the oxidative phosphorylation of BHK cells.

KW - Analgesics—sodium salicylate, effect on hamster kidney cells in culture, generation time, RNA synthesis

KW - Cell culture—hamster kidney cells, effect of sodium salicylate on generation and RNA synthesis

KW - RNA synthesis—hamster kidney cells in culture, effect of sodium salicylate

KW - Sodium salicylate—effect on hamster kidney cells in culture, generation time, RNA synthesis

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Effect of sodium salicylate on hamster cells in vitro

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