Effect of sodium salicylate on hamster cells in vitro

M. Rubenstein, D. Giacomoni, L. M. Pachman*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Doses of sodium salicylate greater than 100 μg/ml increased the generation time of baby hamster kidney (BHK 21) cells in culture from 16 to 35 hr. Exposure to similar doses of salicylate for 18–44 hr resulted in a marked reduction of RNA synthesis. The species of RNA synthesized in the presence of sodium salicylate appeared to be similar to those synthesized by normal cells in the absence of sodium salicylate. Sodium salicylate did not alter the oxidative phosphorylation of BHK cells.

Original languageEnglish (US)
Pages (from-to)756-758
Number of pages3
JournalJournal of Pharmaceutical Sciences
Volume65
Issue number5
DOIs
StatePublished - May 1976

Keywords

  • Analgesics—sodium salicylate, effect on hamster kidney cells in culture, generation time, RNA synthesis
  • Cell culture—hamster kidney cells, effect of sodium salicylate on generation and RNA synthesis
  • RNA synthesis—hamster kidney cells in culture, effect of sodium salicylate
  • Sodium salicylate—effect on hamster kidney cells in culture, generation time, RNA synthesis

ASJC Scopus subject areas

  • Pharmaceutical Science

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