Effect of steroids on structure and endocrine function of duct ligated porcine pancreatic autografts

G. Kyriakides; J. Miller; J. Lifton; J. S. Najarian

Effect of steroids on structure and endocrine function of duct ligated porcine pancreatic autografts

G. Kyriakides, J. Miller, J. Lifton, J. S. Najarian

Surgery, Transplant Surgery Division

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Segmental duct ligated pancreas autotransplants in pigs undergo significant inflammation, fibrosis and architectural distortion with decrease in insulin production at one to two wk intervals following transplantation. Daily administration of methylprednisolone sodium succinate prevents the morphologic changes and preserves normal insulin production. It is speculated that steroids exert their beneficial effect by the prevention of fibrosis and by membrane stabilization, preserving cellular integrity which would inhibit autodigestive phenomena, thereby maintaining the normal morphology and function of the graft.

Original language	English (US)
Pages (from-to)	384-386
Number of pages	3
Journal	Surgical forum
Volume	Vol. 25
State	Published - Jan 1 1974

ASJC Scopus subject areas

Surgery

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title = "Effect of steroids on structure and endocrine function of duct ligated porcine pancreatic autografts",

abstract = "Segmental duct ligated pancreas autotransplants in pigs undergo significant inflammation, fibrosis and architectural distortion with decrease in insulin production at one to two wk intervals following transplantation. Daily administration of methylprednisolone sodium succinate prevents the morphologic changes and preserves normal insulin production. It is speculated that steroids exert their beneficial effect by the prevention of fibrosis and by membrane stabilization, preserving cellular integrity which would inhibit autodigestive phenomena, thereby maintaining the normal morphology and function of the graft.",

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AU - Miller, J.

AU - Lifton, J.

AU - Najarian, J. S.

PY - 1974/1/1

Y1 - 1974/1/1

N2 - Segmental duct ligated pancreas autotransplants in pigs undergo significant inflammation, fibrosis and architectural distortion with decrease in insulin production at one to two wk intervals following transplantation. Daily administration of methylprednisolone sodium succinate prevents the morphologic changes and preserves normal insulin production. It is speculated that steroids exert their beneficial effect by the prevention of fibrosis and by membrane stabilization, preserving cellular integrity which would inhibit autodigestive phenomena, thereby maintaining the normal morphology and function of the graft.

AB - Segmental duct ligated pancreas autotransplants in pigs undergo significant inflammation, fibrosis and architectural distortion with decrease in insulin production at one to two wk intervals following transplantation. Daily administration of methylprednisolone sodium succinate prevents the morphologic changes and preserves normal insulin production. It is speculated that steroids exert their beneficial effect by the prevention of fibrosis and by membrane stabilization, preserving cellular integrity which would inhibit autodigestive phenomena, thereby maintaining the normal morphology and function of the graft.

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