Effect of stress and temperature on the micromechanics of creep in highly irradiated bone and dentin

Anjali Singhal; Alix C. Deymier-Black; Jonathan D. Almer; David C. Dunand

doi:10.1016/j.msec.2012.12.069

Effect of stress and temperature on the micromechanics of creep in highly irradiated bone and dentin

Anjali Singhal^*, Alix C. Deymier-Black, Jonathan D. Almer, David C. Dunand

^*Corresponding author for this work

Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Synchrotron X-ray diffraction is used to study in situ the evolution of phase strains during compressive creep deformation in bovine bone and dentin for a range of compressive stresses and irradiation rates, at ambient and body temperatures. In all cases, compressive strains in the collagen phase increase with increasing creep time (and concomitant irradiation), reflecting macroscopic deformation of the sample. By contrast, compressive elastic strains in the hydroxyapatite (HAP) phase, created upon initial application of compressive load on the sample, decrease with increasing time (and irradiation) for all conditions; this load shedding behavior is consistent with damage at the HAP-collagen interface due to the high irradiation doses (from ∼ 100 to ∼ 9,000 kGy). Both the HAP and fibril strain rates increase with applied compressive stress, temperature and irradiation rate, which is indicative of greater collagen molecular sliding at the HAP-collagen interface and greater intermolecular sliding (i.e., plastic deformation) within the collagen network. The temperature sensitivity confirms that testing at body temperature, rather than ambient temperature, is necessary to assess the in vivo behavior of bone and teeth. The characteristic pattern of HAP strain evolution with time differs quantitatively between bone and dentin, and may reflect their different structural organization.

Original language	English (US)
Pages (from-to)	1467-1475
Number of pages	9
Journal	Materials Science and Engineering C
Volume	33
Issue number	3
DOIs	https://doi.org/10.1016/j.msec.2012.12.069
State	Published - Apr 1 2013

Funding

The authors thank Prof. L. Catherine Brinson (NU), Dr. S.R. Stock (NU), Mr. Fang Yuan (NU) and Dr. Dean R. Haeffner (APS) for numerous useful discussions throughout this work. They also acknowledge Dr. Yu-chen Karen Chen-Wiegart (NU) and Mr. Fang Yuan (NU) for their help with the experiments at the APS. This research was performed at station 1-ID of XOR-APS. Use of the Advanced Photon Source was supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences , under Contract No. DE-AC02-06CH11357 . Partial funding was provided to A.C.D.B. by a National Defense Science and Engineering Graduate Fellowship from the Department of Defense and by a Graduate Fellowship from the National Science Foundation .

Keywords

Bone
Creep
Dentin
Irradiation
Synchrotron X-ray diffraction
Temperature

ASJC Scopus subject areas

General Medicine

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10.1016/j.msec.2012.12.069

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title = "Effect of stress and temperature on the micromechanics of creep in highly irradiated bone and dentin",

abstract = "Synchrotron X-ray diffraction is used to study in situ the evolution of phase strains during compressive creep deformation in bovine bone and dentin for a range of compressive stresses and irradiation rates, at ambient and body temperatures. In all cases, compressive strains in the collagen phase increase with increasing creep time (and concomitant irradiation), reflecting macroscopic deformation of the sample. By contrast, compressive elastic strains in the hydroxyapatite (HAP) phase, created upon initial application of compressive load on the sample, decrease with increasing time (and irradiation) for all conditions; this load shedding behavior is consistent with damage at the HAP-collagen interface due to the high irradiation doses (from ∼ 100 to ∼ 9,000 kGy). Both the HAP and fibril strain rates increase with applied compressive stress, temperature and irradiation rate, which is indicative of greater collagen molecular sliding at the HAP-collagen interface and greater intermolecular sliding (i.e., plastic deformation) within the collagen network. The temperature sensitivity confirms that testing at body temperature, rather than ambient temperature, is necessary to assess the in vivo behavior of bone and teeth. The characteristic pattern of HAP strain evolution with time differs quantitatively between bone and dentin, and may reflect their different structural organization.",

keywords = "Bone, Creep, Dentin, Irradiation, Synchrotron X-ray diffraction, Temperature",

author = "Anjali Singhal and Deymier-Black, {Alix C.} and Almer, {Jonathan D.} and Dunand, {David C.}",

note = "Funding Information: The authors thank Prof. L. Catherine Brinson (NU), Dr. S.R. Stock (NU), Mr. Fang Yuan (NU) and Dr. Dean R. Haeffner (APS) for numerous useful discussions throughout this work. They also acknowledge Dr. Yu-chen Karen Chen-Wiegart (NU) and Mr. Fang Yuan (NU) for their help with the experiments at the APS. This research was performed at station 1-ID of XOR-APS. Use of the Advanced Photon Source was supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences , under Contract No. DE-AC02-06CH11357 . Partial funding was provided to A.C.D.B. by a National Defense Science and Engineering Graduate Fellowship from the Department of Defense and by a Graduate Fellowship from the National Science Foundation . ",

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AU - Dunand, David C.

N1 - Funding Information: The authors thank Prof. L. Catherine Brinson (NU), Dr. S.R. Stock (NU), Mr. Fang Yuan (NU) and Dr. Dean R. Haeffner (APS) for numerous useful discussions throughout this work. They also acknowledge Dr. Yu-chen Karen Chen-Wiegart (NU) and Mr. Fang Yuan (NU) for their help with the experiments at the APS. This research was performed at station 1-ID of XOR-APS. Use of the Advanced Photon Source was supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences , under Contract No. DE-AC02-06CH11357 . Partial funding was provided to A.C.D.B. by a National Defense Science and Engineering Graduate Fellowship from the Department of Defense and by a Graduate Fellowship from the National Science Foundation .

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N2 - Synchrotron X-ray diffraction is used to study in situ the evolution of phase strains during compressive creep deformation in bovine bone and dentin for a range of compressive stresses and irradiation rates, at ambient and body temperatures. In all cases, compressive strains in the collagen phase increase with increasing creep time (and concomitant irradiation), reflecting macroscopic deformation of the sample. By contrast, compressive elastic strains in the hydroxyapatite (HAP) phase, created upon initial application of compressive load on the sample, decrease with increasing time (and irradiation) for all conditions; this load shedding behavior is consistent with damage at the HAP-collagen interface due to the high irradiation doses (from ∼ 100 to ∼ 9,000 kGy). Both the HAP and fibril strain rates increase with applied compressive stress, temperature and irradiation rate, which is indicative of greater collagen molecular sliding at the HAP-collagen interface and greater intermolecular sliding (i.e., plastic deformation) within the collagen network. The temperature sensitivity confirms that testing at body temperature, rather than ambient temperature, is necessary to assess the in vivo behavior of bone and teeth. The characteristic pattern of HAP strain evolution with time differs quantitatively between bone and dentin, and may reflect their different structural organization.

AB - Synchrotron X-ray diffraction is used to study in situ the evolution of phase strains during compressive creep deformation in bovine bone and dentin for a range of compressive stresses and irradiation rates, at ambient and body temperatures. In all cases, compressive strains in the collagen phase increase with increasing creep time (and concomitant irradiation), reflecting macroscopic deformation of the sample. By contrast, compressive elastic strains in the hydroxyapatite (HAP) phase, created upon initial application of compressive load on the sample, decrease with increasing time (and irradiation) for all conditions; this load shedding behavior is consistent with damage at the HAP-collagen interface due to the high irradiation doses (from ∼ 100 to ∼ 9,000 kGy). Both the HAP and fibril strain rates increase with applied compressive stress, temperature and irradiation rate, which is indicative of greater collagen molecular sliding at the HAP-collagen interface and greater intermolecular sliding (i.e., plastic deformation) within the collagen network. The temperature sensitivity confirms that testing at body temperature, rather than ambient temperature, is necessary to assess the in vivo behavior of bone and teeth. The characteristic pattern of HAP strain evolution with time differs quantitatively between bone and dentin, and may reflect their different structural organization.

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KW - Synchrotron X-ray diffraction

KW - Temperature

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ER -

Effect of stress and temperature on the micromechanics of creep in highly irradiated bone and dentin

Abstract

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Keywords

ASJC Scopus subject areas

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