Effect of tetramethylpyrazine on lymphocytes proliferation response of murine splenocytes

J. Liu*, W. Qiang, S. Ye

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The effect of tetramethylpyrazine (TMP) on lymphocytes proliferation response (LPR) detected by 3H-TdR incorporation into murine monocytes. The results showed that TTMP at the concentration of 100-1000 micrograms/ml inhibited LPR in normal mice and B14-melanoma bearing mice in vitro the effect was dose-dependent. It was also found TTMP could stimulate LPR to Con A at the concentration of 1 micron/ml in normal mice, and at the concentration of 100-1000 micrograms/ml in B16-melanoma bearing mice. But TTMP inhibited LPR to Con A at the concentration of 100-1000 micrograms/ml in normal mice. The restoration of LPR to PHA and increasing 3H-TdR incorporation into splenocytes were found in vivo in B16-melanoma bearing mice after treatment with TTMP. The data indicates that TTMP has an immune modulation.

Original languageEnglish (US)
Pages (from-to)177-179
Number of pages3
JournalHua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao / [bian ji zhe, Hua xi yi ke da xue xue bao bian wei hui]
Volume26
Issue number2
StatePublished - Jun 1995

ASJC Scopus subject areas

  • Medicine(all)

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