The effect of tetramethylpyrazine (TMP) on lymphocytes proliferation response (LPR) detected by 3H-TdR incorporation into murine monocytes. The results showed that TTMP at the concentration of 100-1000 micrograms/ml inhibited LPR in normal mice and B14-melanoma bearing mice in vitro the effect was dose-dependent. It was also found TTMP could stimulate LPR to Con A at the concentration of 1 micron/ml in normal mice, and at the concentration of 100-1000 micrograms/ml in B16-melanoma bearing mice. But TTMP inhibited LPR to Con A at the concentration of 100-1000 micrograms/ml in normal mice. The restoration of LPR to PHA and increasing 3H-TdR incorporation into splenocytes were found in vivo in B16-melanoma bearing mice after treatment with TTMP. The data indicates that TTMP has an immune modulation.
|Original language||English (US)|
|Number of pages||3|
|Journal||Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao / [bian ji zhe, Hua xi yi ke da xue xue bao bian wei hui]|
|State||Published - Jun 1995|
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