Effect of the calcium ionophore A23187 and aspirin on histamine release in vitro from leukocytes of aspirin-intolerant donors

Bruce S. Bochner, Larry L. Thomas, Lucille Godnik, Max Samter*

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

In vitro histamine release from leukocytes of 10 aspirin-intolerant donors in response to the calcium ionophore A23187 and aspirin was compared to that of controls. Incubation with A23187 induced a con- centration-dependent histamine release from leukocytes of all donors. At 0.1 and 0.2 μg/ml A23187, release from leukocytes of aspirin-intolerant donors was significantly less (p < 0.01) than that of controls. Preincubation with aspirin failed to alter spontaneous or A23187-stimulated histamine release. Leukocytes of aspirin-intolerant donors do not demonstrate an enhanced sensitivity to histamine release stimulated by aspirin or A23187.

Original languageEnglish (US)
Pages (from-to)104-107
Number of pages4
JournalInternational archives of allergy and immunology
Volume74
Issue number2
DOIs
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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