Effect of time-restricted eating on sex hormone levels in premenopausal and postmenopausal females

Faiza Kalam; Rand T. Akasheh; Sofia Cienfuegos; Aparna Ankireddy; Kelsey Gabel; Mark Ezpeleta; Shuhao Lin; Chandra M. Tamatam; Sekhar P. Reddy; Bonnie J Spring; Seema A. Khan; Krista A. Varady

doi:10.1002/oby.23562

Effect of time-restricted eating on sex hormone levels in premenopausal and postmenopausal females

Faiza Kalam, Rand T. Akasheh, Sofia Cienfuegos, Aparna Ankireddy, Kelsey Gabel, Mark Ezpeleta, Shuhao Lin, Chandra M. Tamatam, Sekhar P. Reddy, Bonnie J Spring, Seema A. Khan, Krista A. Varady^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Objective: Concerns have been raised regarding the impact of time-restricted eating (TRE) on sex hormones in females. This study examined how TRE affects sex steroids in premenopausal and postmenopausal females. Methods: This is a secondary analysis of an 8-week TRE study (4- to 6-hour eating window) conducted in adults with obesity. Men and perimenopausal females were excluded. Females were classified into two groups based on menstrual status: premenopausal (n = 12) or postmenopausal (n = 11). Results: After 8 weeks, body weight decreased in premenopausal females (−3% ± 2%) and postmenopausal females (−4% ± 2%) (main effect of time, p < 0.001), with no difference between groups (no group × time interaction). Circulating levels of testosterone, androstenedione, and sex hormone binding globulin (SHBG) did not change in either group (no group × time interaction). Dehydroepiandrosterone (DHEA) concentrations decreased (p < 0.05) in premenopausal (−14% ± 32%) and postmenopausal females (−13% ± 34%; main effect of time, p = 0.03), with no difference between groups. Estradiol, estrone, and progesterone were measured only in postmenopausal females, and they remained unchanged. Conclusions: In premenopausal females, androgens and SHBG remained unchanged during TRE, whereas DHEA decreased. In postmenopausal females, estrogens, progesterone, androgens, and SHBG did not change, but DHEA was reduced.

Original language	English (US)
Pages (from-to)	57-62
Number of pages	6
Journal	Obesity
Volume	31
Issue number	S1
DOIs	https://doi.org/10.1002/oby.23562
State	Published - Feb 2023

Funding

This study was funded by the National Institutes of Health (NIH), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Grant/Award Number: R01DK119783 Funding information

ASJC Scopus subject areas

Endocrinology
Nutrition and Dietetics
Medicine (miscellaneous)
Endocrinology, Diabetes and Metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/oby.23562

Cite this

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title = "Effect of time-restricted eating on sex hormone levels in premenopausal and postmenopausal females",

abstract = "Objective: Concerns have been raised regarding the impact of time-restricted eating (TRE) on sex hormones in females. This study examined how TRE affects sex steroids in premenopausal and postmenopausal females. Methods: This is a secondary analysis of an 8-week TRE study (4- to 6-hour eating window) conducted in adults with obesity. Men and perimenopausal females were excluded. Females were classified into two groups based on menstrual status: premenopausal (n = 12) or postmenopausal (n = 11). Results: After 8 weeks, body weight decreased in premenopausal females (−3% ± 2%) and postmenopausal females (−4% ± 2%) (main effect of time, p < 0.001), with no difference between groups (no group × time interaction). Circulating levels of testosterone, androstenedione, and sex hormone binding globulin (SHBG) did not change in either group (no group × time interaction). Dehydroepiandrosterone (DHEA) concentrations decreased (p < 0.05) in premenopausal (−14% ± 32%) and postmenopausal females (−13% ± 34%; main effect of time, p = 0.03), with no difference between groups. Estradiol, estrone, and progesterone were measured only in postmenopausal females, and they remained unchanged. Conclusions: In premenopausal females, androgens and SHBG remained unchanged during TRE, whereas DHEA decreased. In postmenopausal females, estrogens, progesterone, androgens, and SHBG did not change, but DHEA was reduced.",

author = "Faiza Kalam and Akasheh, {Rand T.} and Sofia Cienfuegos and Aparna Ankireddy and Kelsey Gabel and Mark Ezpeleta and Shuhao Lin and Tamatam, {Chandra M.} and Reddy, {Sekhar P.} and Spring, {Bonnie J} and Khan, {Seema A.} and Varady, {Krista A.}",

note = "Publisher Copyright: {\textcopyright} 2022 The Obesity Society.",

year = "2023",

month = feb,

doi = "10.1002/oby.23562",

language = "English (US)",

volume = "31",

pages = "57--62",

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AU - Kalam, Faiza

AU - Akasheh, Rand T.

AU - Cienfuegos, Sofia

AU - Ankireddy, Aparna

AU - Gabel, Kelsey

AU - Ezpeleta, Mark

AU - Lin, Shuhao

AU - Tamatam, Chandra M.

AU - Reddy, Sekhar P.

AU - Spring, Bonnie J

AU - Khan, Seema A.

AU - Varady, Krista A.

PY - 2023/2

Y1 - 2023/2

N2 - Objective: Concerns have been raised regarding the impact of time-restricted eating (TRE) on sex hormones in females. This study examined how TRE affects sex steroids in premenopausal and postmenopausal females. Methods: This is a secondary analysis of an 8-week TRE study (4- to 6-hour eating window) conducted in adults with obesity. Men and perimenopausal females were excluded. Females were classified into two groups based on menstrual status: premenopausal (n = 12) or postmenopausal (n = 11). Results: After 8 weeks, body weight decreased in premenopausal females (−3% ± 2%) and postmenopausal females (−4% ± 2%) (main effect of time, p < 0.001), with no difference between groups (no group × time interaction). Circulating levels of testosterone, androstenedione, and sex hormone binding globulin (SHBG) did not change in either group (no group × time interaction). Dehydroepiandrosterone (DHEA) concentrations decreased (p < 0.05) in premenopausal (−14% ± 32%) and postmenopausal females (−13% ± 34%; main effect of time, p = 0.03), with no difference between groups. Estradiol, estrone, and progesterone were measured only in postmenopausal females, and they remained unchanged. Conclusions: In premenopausal females, androgens and SHBG remained unchanged during TRE, whereas DHEA decreased. In postmenopausal females, estrogens, progesterone, androgens, and SHBG did not change, but DHEA was reduced.

AB - Objective: Concerns have been raised regarding the impact of time-restricted eating (TRE) on sex hormones in females. This study examined how TRE affects sex steroids in premenopausal and postmenopausal females. Methods: This is a secondary analysis of an 8-week TRE study (4- to 6-hour eating window) conducted in adults with obesity. Men and perimenopausal females were excluded. Females were classified into two groups based on menstrual status: premenopausal (n = 12) or postmenopausal (n = 11). Results: After 8 weeks, body weight decreased in premenopausal females (−3% ± 2%) and postmenopausal females (−4% ± 2%) (main effect of time, p < 0.001), with no difference between groups (no group × time interaction). Circulating levels of testosterone, androstenedione, and sex hormone binding globulin (SHBG) did not change in either group (no group × time interaction). Dehydroepiandrosterone (DHEA) concentrations decreased (p < 0.05) in premenopausal (−14% ± 32%) and postmenopausal females (−13% ± 34%; main effect of time, p = 0.03), with no difference between groups. Estradiol, estrone, and progesterone were measured only in postmenopausal females, and they remained unchanged. Conclusions: In premenopausal females, androgens and SHBG remained unchanged during TRE, whereas DHEA decreased. In postmenopausal females, estrogens, progesterone, androgens, and SHBG did not change, but DHEA was reduced.

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Effect of time-restricted eating on sex hormone levels in premenopausal and postmenopausal females

Abstract

Funding

ASJC Scopus subject areas

UN SDGs

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