Effect of tirofiban before primary angioplasty on initial coronary flow and early ST-segment resolution in patients with acute myocardial infarction

Donald E. Cutlip*, Mark J. Ricciardi, Frederick S. Ling, Joseph P. Carrozza, Vineet Dua, Jason Garringer, Satyendra Giri, Ronald P. Caputo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

Sixty-one patients with ST elevation acute myocardial infarction were randomized to receive open-label tirofiban in the emergency room before primary angioplasty versus glycoprotein IIb/IIIa inhibitors administered after initial coronary angiography. Early administration of tirofiban before primary angioplasty resulted in nonsignificant improvement in initial coronary flow (Thrombolysis In Myocardial Infarction trial grade 2 or 3 flow, 39% vs 27%, p >0.20). Patients receiving early tirofiban treatment were more likely to achieve complete (>70%) ST-segment resolution at 90 minutes (69% vs 44%, p = 0.07).

Original languageEnglish (US)
Pages (from-to)977-980
Number of pages4
JournalAmerican Journal of Cardiology
Volume92
Issue number8
DOIs
StatePublished - Oct 15 2003

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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