Effect of tirofiban before primary angioplasty on initial coronary flow and early ST-segment resolution in patients with acute myocardial infarction

Donald E. Cutlip; Mark J. Ricciardi; Frederick S. Ling; Joseph P. Carrozza; Vineet Dua; Jason Garringer; Satyendra Giri; Ronald P. Caputo

doi:10.1016/S0002-9149(03)00983-4

Effect of tirofiban before primary angioplasty on initial coronary flow and early ST-segment resolution in patients with acute myocardial infarction

Donald E. Cutlip^*, Mark J. Ricciardi, Frederick S. Ling, Joseph P. Carrozza, Vineet Dua, Jason Garringer, Satyendra Giri, Ronald P. Caputo

^*Corresponding author for this work

Medicine, Cardiology Division

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

Sixty-one patients with ST elevation acute myocardial infarction were randomized to receive open-label tirofiban in the emergency room before primary angioplasty versus glycoprotein IIb/IIIa inhibitors administered after initial coronary angiography. Early administration of tirofiban before primary angioplasty resulted in nonsignificant improvement in initial coronary flow (Thrombolysis In Myocardial Infarction trial grade 2 or 3 flow, 39% vs 27%, p >0.20). Patients receiving early tirofiban treatment were more likely to achieve complete (>70%) ST-segment resolution at 90 minutes (69% vs 44%, p = 0.07).

Original language	English (US)
Pages (from-to)	977-980
Number of pages	4
Journal	American Journal of Cardiology
Volume	92
Issue number	8
DOIs	https://doi.org/10.1016/S0002-9149(03)00983-4
State	Published - Oct 15 2003

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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title = "Effect of tirofiban before primary angioplasty on initial coronary flow and early ST-segment resolution in patients with acute myocardial infarction",

abstract = "Sixty-one patients with ST elevation acute myocardial infarction were randomized to receive open-label tirofiban in the emergency room before primary angioplasty versus glycoprotein IIb/IIIa inhibitors administered after initial coronary angiography. Early administration of tirofiban before primary angioplasty resulted in nonsignificant improvement in initial coronary flow (Thrombolysis In Myocardial Infarction trial grade 2 or 3 flow, 39% vs 27%, p >0.20). Patients receiving early tirofiban treatment were more likely to achieve complete (>70%) ST-segment resolution at 90 minutes (69% vs 44%, p = 0.07).",

author = "Cutlip, {Donald E.} and Ricciardi, {Mark J.} and Ling, {Frederick S.} and Carrozza, {Joseph P.} and Vineet Dua and Jason Garringer and Satyendra Giri and Caputo, {Ronald P.}",

note = "Funding Information: This report was supported by an educational grant from Merck and Co., Inc., Whitehouse Station, New Jersey. ",

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T1 - Effect of tirofiban before primary angioplasty on initial coronary flow and early ST-segment resolution in patients with acute myocardial infarction

AU - Cutlip, Donald E.

AU - Ricciardi, Mark J.

AU - Ling, Frederick S.

AU - Carrozza, Joseph P.

AU - Dua, Vineet

AU - Garringer, Jason

AU - Giri, Satyendra

AU - Caputo, Ronald P.

N1 - Funding Information: This report was supported by an educational grant from Merck and Co., Inc., Whitehouse Station, New Jersey.

PY - 2003/10/15

Y1 - 2003/10/15

N2 - Sixty-one patients with ST elevation acute myocardial infarction were randomized to receive open-label tirofiban in the emergency room before primary angioplasty versus glycoprotein IIb/IIIa inhibitors administered after initial coronary angiography. Early administration of tirofiban before primary angioplasty resulted in nonsignificant improvement in initial coronary flow (Thrombolysis In Myocardial Infarction trial grade 2 or 3 flow, 39% vs 27%, p >0.20). Patients receiving early tirofiban treatment were more likely to achieve complete (>70%) ST-segment resolution at 90 minutes (69% vs 44%, p = 0.07).

AB - Sixty-one patients with ST elevation acute myocardial infarction were randomized to receive open-label tirofiban in the emergency room before primary angioplasty versus glycoprotein IIb/IIIa inhibitors administered after initial coronary angiography. Early administration of tirofiban before primary angioplasty resulted in nonsignificant improvement in initial coronary flow (Thrombolysis In Myocardial Infarction trial grade 2 or 3 flow, 39% vs 27%, p >0.20). Patients receiving early tirofiban treatment were more likely to achieve complete (>70%) ST-segment resolution at 90 minutes (69% vs 44%, p = 0.07).

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Effect of tirofiban before primary angioplasty on initial coronary flow and early ST-segment resolution in patients with acute myocardial infarction

Abstract

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