Abstract
TL-99 and 3-PPP, two putative dopamine autoreceptor agonists, effectively suppressed serum prolactin (PRL) concentrations in rats treated with α-methyltyrosine. In addition, the secretion of PRL from anterior pituitary tissue under in vitro conditions was significantly inhibited by TL-99 and 3-PPP. These findings are supportive of the view that TL-99 and 3-PPP exert a dopamine agonist action at dopamine receptors in the anterior pituitary gland.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 423-425 |
| Number of pages | 3 |
| Journal | European Journal of Pharmacology |
| Volume | 90 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jun 17 1983 |
Keywords
- 3-PPP
- Dopamine agonist
- Prolactin
- TL-99
ASJC Scopus subject areas
- Pharmacology
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Gudelsky, G. A., Passaro, E., & Meltzer, H. Y. (1983). Effect of two dopamine agonists, TL-99 and 3-PPP, on prolactin secretion in the rat. European Journal of Pharmacology, 90(4), 423-425. https://doi.org/10.1016/0014-2999(83)90565-4