Abstract
TL-99 and 3-PPP, two putative dopamine autoreceptor agonists, effectively suppressed serum prolactin (PRL) concentrations in rats treated with α-methyltyrosine. In addition, the secretion of PRL from anterior pituitary tissue under in vitro conditions was significantly inhibited by TL-99 and 3-PPP. These findings are supportive of the view that TL-99 and 3-PPP exert a dopamine agonist action at dopamine receptors in the anterior pituitary gland.
Original language | English (US) |
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Pages (from-to) | 423-425 |
Number of pages | 3 |
Journal | European Journal of Pharmacology |
Volume | 90 |
Issue number | 4 |
DOIs | |
State | Published - Jun 17 1983 |
Keywords
- 3-PPP
- Dopamine agonist
- Prolactin
- TL-99
ASJC Scopus subject areas
- Pharmacology