Effect of two dopamine agonists, TL-99 and 3-PPP, on prolactin secretion in the rat

Gary A. Gudelsky; Erasmo Passaro; Herbert Y. Meltzer

doi:10.1016/0014-2999(83)90565-4

Effect of two dopamine agonists, TL-99 and 3-PPP, on prolactin secretion in the rat

Gary A. Gudelsky^*, Erasmo Passaro, Herbert Y. Meltzer

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

TL-99 and 3-PPP, two putative dopamine autoreceptor agonists, effectively suppressed serum prolactin (PRL) concentrations in rats treated with α-methyltyrosine. In addition, the secretion of PRL from anterior pituitary tissue under in vitro conditions was significantly inhibited by TL-99 and 3-PPP. These findings are supportive of the view that TL-99 and 3-PPP exert a dopamine agonist action at dopamine receptors in the anterior pituitary gland.

Original language	English (US)
Pages (from-to)	423-425
Number of pages	3
Journal	European Journal of Pharmacology
Volume	90
Issue number	4
DOIs	https://doi.org/10.1016/0014-2999(83)90565-4
State	Published - Jun 17 1983

Keywords

3-PPP
Dopamine agonist
Prolactin
TL-99

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(83)90565-4

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title = "Effect of two dopamine agonists, TL-99 and 3-PPP, on prolactin secretion in the rat",

abstract = "TL-99 and 3-PPP, two putative dopamine autoreceptor agonists, effectively suppressed serum prolactin (PRL) concentrations in rats treated with α-methyltyrosine. In addition, the secretion of PRL from anterior pituitary tissue under in vitro conditions was significantly inhibited by TL-99 and 3-PPP. These findings are supportive of the view that TL-99 and 3-PPP exert a dopamine agonist action at dopamine receptors in the anterior pituitary gland.",

keywords = "3-PPP, Dopamine agonist, Prolactin, TL-99",

author = "Gudelsky, {Gary A.} and Erasmo Passaro and Meltzer, {Herbert Y.}",

note = "Funding Information: The editoriaal ssistancoef Mrs. GeorgiaG ilberti s gratefully acknowledgedT.h is work was supportebdy a Research StarteGr rantfrom the PMA and by USPHS MH 30,938a nd by theD epartmenotf MentalH ealthS, tateo f lllinois. HYM is a recipienotf USPHS MH 47,808.",

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doi = "10.1016/0014-2999(83)90565-4",

language = "English (US)",

volume = "90",

pages = "423--425",

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T1 - Effect of two dopamine agonists, TL-99 and 3-PPP, on prolactin secretion in the rat

AU - Gudelsky, Gary A.

AU - Passaro, Erasmo

AU - Meltzer, Herbert Y.

N1 - Funding Information: The editoriaal ssistancoef Mrs. GeorgiaG ilberti s gratefully acknowledgedT.h is work was supportebdy a Research StarteGr rantfrom the PMA and by USPHS MH 30,938a nd by theD epartmenotf MentalH ealthS, tateo f lllinois. HYM is a recipienotf USPHS MH 47,808.

PY - 1983/6/17

Y1 - 1983/6/17

N2 - TL-99 and 3-PPP, two putative dopamine autoreceptor agonists, effectively suppressed serum prolactin (PRL) concentrations in rats treated with α-methyltyrosine. In addition, the secretion of PRL from anterior pituitary tissue under in vitro conditions was significantly inhibited by TL-99 and 3-PPP. These findings are supportive of the view that TL-99 and 3-PPP exert a dopamine agonist action at dopamine receptors in the anterior pituitary gland.

AB - TL-99 and 3-PPP, two putative dopamine autoreceptor agonists, effectively suppressed serum prolactin (PRL) concentrations in rats treated with α-methyltyrosine. In addition, the secretion of PRL from anterior pituitary tissue under in vitro conditions was significantly inhibited by TL-99 and 3-PPP. These findings are supportive of the view that TL-99 and 3-PPP exert a dopamine agonist action at dopamine receptors in the anterior pituitary gland.

KW - 3-PPP

KW - Dopamine agonist

KW - Prolactin

KW - TL-99

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Effect of two dopamine agonists, TL-99 and 3-PPP, on prolactin secretion in the rat

Abstract

Keywords

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