Effect of two dopamine agonists, TL-99 and 3-PPP, on prolactin secretion in the rat

Gary A. Gudelsky*, Erasmo Passaro, Herbert Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

TL-99 and 3-PPP, two putative dopamine autoreceptor agonists, effectively suppressed serum prolactin (PRL) concentrations in rats treated with α-methyltyrosine. In addition, the secretion of PRL from anterior pituitary tissue under in vitro conditions was significantly inhibited by TL-99 and 3-PPP. These findings are supportive of the view that TL-99 and 3-PPP exert a dopamine agonist action at dopamine receptors in the anterior pituitary gland.

Original languageEnglish (US)
Pages (from-to)423-425
Number of pages3
JournalEuropean Journal of Pharmacology
Volume90
Issue number4
DOIs
StatePublished - Jun 17 1983

Keywords

  • 3-PPP
  • Dopamine agonist
  • Prolactin
  • TL-99

ASJC Scopus subject areas

  • Pharmacology

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