Effect of vascular endothelial growth factor on laryngeal wound healing in rabbits

James W. Schroeder*, Jeffrey C. Rastatter, David L. Walner

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Objective: Study the effects of vascular endothelial growth factor (VEGF) on laryngeal wound healing in a rabbit model. Study Design: Prospective, randomized, blinded. Methods: The anterior cricoid cartilage of 10 rabbits was split and a VEGF-soaked collagen sponge was sewn between the cut edges. In 10 control animals, the collagen sponge was soaked with phosphate-buffered saline solution. The larynx was harvested on day 10. The degree of epithelial closure, the degree of soft tissue closure, and the presence of inflammatory cells was graded. Results: There was complete epithelial closure in the control group. There was a slightly higher, but not statistically significant, grade of soft tissue closure in the experimental group. The experimental group had a lower but not statistically significant acute inflammatory response score. Conclusions: The topical application of VEGF through an implanted collagen sponge to an anterior, subglottic incision in a rabbit has no significant effect on tracheal luminal epithelial closure, acute inflammatory response, or soft tissue repair at postsurgical day 10.

Original languageEnglish (US)
Pages (from-to)465-470
Number of pages6
JournalOtolaryngology - Head and Neck Surgery
Volume137
Issue number3
DOIs
StatePublished - Sep 1 2007

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

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