Effect of viral and bacterial pneumonias on cell mediated immunity in humans

C. A. Kauffman; C. C. Linnemann; G. M. Schiff; J. P. Phair

doi:10.1128/iai.13.1.78-83.1976

Effect of viral and bacterial pneumonias on cell mediated immunity in humans

C. A. Kauffman, C. C. Linnemann, G. M. Schiff, J. P. Phair

Medicine, Infectious Diseases Division

Research output: Contribution to journal › Article › peer-review

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Abstract

Cell mediated immunity (CMI) was assessed during infection and after convalescence in 12 patients with influenza pneumonia and 10 patients with bacterial pneumonia. The patients with influenza pneumonia had a marked impairment of skin test reactivity, and their lymphocytes showed a diminished response to phytohemagglutinin and streptokinase streptodornase stimulation in vitro. Suppression of CMI was related to the severity of the pneumonia. Patients with bacterial pneumonia showed as great a suppression of the response to phytohemagglutinin and streptokinase streptodornase as the patients with viral pneumonia. All parameters of CMI returned to normal in both groups after convalescence. The depression of CMI could not be related to a decrease in the number of thymus derived lymphocytes or to serum suppressive factors in these patients.

Original language	English (US)
Pages (from-to)	78-83
Number of pages	6
Journal	Infection and immunity
Volume	13
Issue number	1
DOIs	https://doi.org/10.1128/iai.13.1.78-83.1976
State	Published - 1976

ASJC Scopus subject areas

Infectious Diseases
Parasitology
Microbiology
Immunology

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10.1128/iai.13.1.78-83.1976

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AU - Schiff, G. M.

AU - Phair, J. P.

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AB - Cell mediated immunity (CMI) was assessed during infection and after convalescence in 12 patients with influenza pneumonia and 10 patients with bacterial pneumonia. The patients with influenza pneumonia had a marked impairment of skin test reactivity, and their lymphocytes showed a diminished response to phytohemagglutinin and streptokinase streptodornase stimulation in vitro. Suppression of CMI was related to the severity of the pneumonia. Patients with bacterial pneumonia showed as great a suppression of the response to phytohemagglutinin and streptokinase streptodornase as the patients with viral pneumonia. All parameters of CMI returned to normal in both groups after convalescence. The depression of CMI could not be related to a decrease in the number of thymus derived lymphocytes or to serum suppressive factors in these patients.

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Effect of viral and bacterial pneumonias on cell mediated immunity in humans

Abstract

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