TY - JOUR
T1 - Effect of Warfarin on Survival in Small Cell Carcinoma of the Lung
T2 - Veterans Administration Study No. 75
AU - Zacharski, Leo R.
AU - O'donnell, Joseph R.
AU - Henderson, William G.
AU - Rickles, Frederick R.
AU - Edwards, Richard
AU - Forman, Walter B.
AU - Cornell, C. J.
AU - Forcier, R. Jackson
AU - Headley, Elwood
AU - Kim, Sang Hee
AU - O'dell, Robert
AU - Tornyos, Karl
AU - Kwaan, Hau C.
PY - 1981/2/27
Y1 - 1981/2/27
N2 - In a controlled, randomized study, survival of patients with small cell carcinoma of the lung (SCCL) was prolonged on addition of warfarin sodium to combination chemotherapy plus radiation therapy. Median survival for 25 control patients was 24 weeks and for 25 warfarin-treated patients was 50 weeks. This difference could not be accounted for by differences between groups in performance status, extent of disease, age, or sex. The survival advantage associated with warfarin administration was observed both for patients with extensive disease and for those who failed to achieve complete or partial remission. The warfarin-treated group also demonstrated a significantly increased time to first evidence of disease progression. These results suggest that warfarin may be useful in the treatment of SCCL and also support the hypothesis that the blood coagulation mechanism may be involved in the growth and spread of cancer in man. (JAMA 1981;245:831-835).
AB - In a controlled, randomized study, survival of patients with small cell carcinoma of the lung (SCCL) was prolonged on addition of warfarin sodium to combination chemotherapy plus radiation therapy. Median survival for 25 control patients was 24 weeks and for 25 warfarin-treated patients was 50 weeks. This difference could not be accounted for by differences between groups in performance status, extent of disease, age, or sex. The survival advantage associated with warfarin administration was observed both for patients with extensive disease and for those who failed to achieve complete or partial remission. The warfarin-treated group also demonstrated a significantly increased time to first evidence of disease progression. These results suggest that warfarin may be useful in the treatment of SCCL and also support the hypothesis that the blood coagulation mechanism may be involved in the growth and spread of cancer in man. (JAMA 1981;245:831-835).
UR - http://www.scopus.com/inward/record.url?scp=84944970723&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84944970723&partnerID=8YFLogxK
U2 - 10.1001/jama.1981.03310330021017
DO - 10.1001/jama.1981.03310330021017
M3 - Article
SN - 0098-7484
VL - 245
SP - 831
EP - 835
JO - JAMA: The Journal of the American Medical Association
JF - JAMA: The Journal of the American Medical Association
IS - 8
ER -
