Effective Wound Healing Enabled by Discrete Alternative Electric Fields from Wearable Nanogenerators

Yin Long, Hao Wei, Jun Li, Guang Yao, Bo Yu, Dalong Ni, Angela L. Gibson, Xiaoli Lan, Yadong Jiang, Weibo Cai*, Xudong Wang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

108 Scopus citations


Skin wound healing is a major health care issue. While electric stimulations have been known for decades to be effective for facilitating skin wound recovery, practical applications are still largely limited by the clumsy electrical systems. Here, we report an efficient electrical bandage for accelerated skin wound healing. On the bandage, an alternating discrete electric field is generated by a wearable nanogenerator by converting mechanical displacement from skin movements into electricity. Rat studies demonstrated rapid closure of a full-thickness rectangular skin wound within 3 days as compared to 12 days of usual contraction-based healing processes in rodents. From in vitro studies, the accelerated skin wound healing was attributed to electric field-facilitated fibroblast migration, proliferation, and transdifferentiation. This self-powered electric-dressing modality could lead to a facile therapeutic strategy for nonhealing skin wound treatment.

Original languageEnglish (US)
Pages (from-to)12533-12540
Number of pages8
JournalACS nano
Issue number12
StatePublished - Dec 26 2018


  • nanogenerator
  • physical therapy
  • self-powering
  • wearable device
  • wound healing

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)


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