Effective Wound Healing Enabled by Discrete Alternative Electric Fields from Wearable Nanogenerators

Yin Long; Hao Wei; Jun Li; Guang Yao; Bo Yu; Dalong Ni; Angela L. Gibson; Xiaoli Lan; Yadong Jiang; Weibo Cai; Xudong Wang

doi:10.1021/acsnano.8b07038

Effective Wound Healing Enabled by Discrete Alternative Electric Fields from Wearable Nanogenerators

Yin Long, Hao Wei, Jun Li, Guang Yao, Bo Yu, Dalong Ni, Angela L. Gibson, Xiaoli Lan, Yadong Jiang, Weibo Cai^*, Xudong Wang

^*Corresponding author for this work

Radiology

Research output: Contribution to journal › Article › peer-review

108 Scopus citations

Abstract

Skin wound healing is a major health care issue. While electric stimulations have been known for decades to be effective for facilitating skin wound recovery, practical applications are still largely limited by the clumsy electrical systems. Here, we report an efficient electrical bandage for accelerated skin wound healing. On the bandage, an alternating discrete electric field is generated by a wearable nanogenerator by converting mechanical displacement from skin movements into electricity. Rat studies demonstrated rapid closure of a full-thickness rectangular skin wound within 3 days as compared to 12 days of usual contraction-based healing processes in rodents. From in vitro studies, the accelerated skin wound healing was attributed to electric field-facilitated fibroblast migration, proliferation, and transdifferentiation. This self-powered electric-dressing modality could lead to a facile therapeutic strategy for nonhealing skin wound treatment.

Original language	English (US)
Pages (from-to)	12533-12540
Number of pages	8
Journal	ACS nano
Volume	12
Issue number	12
DOIs	https://doi.org/10.1021/acsnano.8b07038
State	Published - Dec 26 2018

Keywords

nanogenerator
physical therapy
self-powering
wearable device
wound healing

ASJC Scopus subject areas

Materials Science(all)
Engineering(all)
Physics and Astronomy(all)

Access to Document

10.1021/acsnano.8b07038

Cite this

@article{4c844eedf279464d8f5bb31eca091389,

title = "Effective Wound Healing Enabled by Discrete Alternative Electric Fields from Wearable Nanogenerators",

abstract = "Skin wound healing is a major health care issue. While electric stimulations have been known for decades to be effective for facilitating skin wound recovery, practical applications are still largely limited by the clumsy electrical systems. Here, we report an efficient electrical bandage for accelerated skin wound healing. On the bandage, an alternating discrete electric field is generated by a wearable nanogenerator by converting mechanical displacement from skin movements into electricity. Rat studies demonstrated rapid closure of a full-thickness rectangular skin wound within 3 days as compared to 12 days of usual contraction-based healing processes in rodents. From in vitro studies, the accelerated skin wound healing was attributed to electric field-facilitated fibroblast migration, proliferation, and transdifferentiation. This self-powered electric-dressing modality could lead to a facile therapeutic strategy for nonhealing skin wound treatment.",

keywords = "nanogenerator, physical therapy, self-powering, wearable device, wound healing",

author = "Yin Long and Hao Wei and Jun Li and Guang Yao and Bo Yu and Dalong Ni and Gibson, {Angela L.} and Xiaoli Lan and Yadong Jiang and Weibo Cai and Xudong Wang",

note = "Funding Information: This publication was supported by the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health under Award Nos. R01EB021336 and P30CA014520. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: Copyright {\textcopyright} 2018 American Chemical Society.",

year = "2018",

month = dec,

day = "26",

doi = "10.1021/acsnano.8b07038",

language = "English (US)",

volume = "12",

pages = "12533--12540",

journal = "ACS Nano",

issn = "1936-0851",

publisher = "American Chemical Society",

number = "12",

}

TY - JOUR

T1 - Effective Wound Healing Enabled by Discrete Alternative Electric Fields from Wearable Nanogenerators

AU - Long, Yin

AU - Wei, Hao

AU - Li, Jun

AU - Yao, Guang

AU - Yu, Bo

AU - Ni, Dalong

AU - Gibson, Angela L.

AU - Lan, Xiaoli

AU - Jiang, Yadong

AU - Cai, Weibo

AU - Wang, Xudong

N1 - Funding Information: This publication was supported by the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health under Award Nos. R01EB021336 and P30CA014520. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: Copyright © 2018 American Chemical Society.

PY - 2018/12/26

Y1 - 2018/12/26

N2 - Skin wound healing is a major health care issue. While electric stimulations have been known for decades to be effective for facilitating skin wound recovery, practical applications are still largely limited by the clumsy electrical systems. Here, we report an efficient electrical bandage for accelerated skin wound healing. On the bandage, an alternating discrete electric field is generated by a wearable nanogenerator by converting mechanical displacement from skin movements into electricity. Rat studies demonstrated rapid closure of a full-thickness rectangular skin wound within 3 days as compared to 12 days of usual contraction-based healing processes in rodents. From in vitro studies, the accelerated skin wound healing was attributed to electric field-facilitated fibroblast migration, proliferation, and transdifferentiation. This self-powered electric-dressing modality could lead to a facile therapeutic strategy for nonhealing skin wound treatment.

AB - Skin wound healing is a major health care issue. While electric stimulations have been known for decades to be effective for facilitating skin wound recovery, practical applications are still largely limited by the clumsy electrical systems. Here, we report an efficient electrical bandage for accelerated skin wound healing. On the bandage, an alternating discrete electric field is generated by a wearable nanogenerator by converting mechanical displacement from skin movements into electricity. Rat studies demonstrated rapid closure of a full-thickness rectangular skin wound within 3 days as compared to 12 days of usual contraction-based healing processes in rodents. From in vitro studies, the accelerated skin wound healing was attributed to electric field-facilitated fibroblast migration, proliferation, and transdifferentiation. This self-powered electric-dressing modality could lead to a facile therapeutic strategy for nonhealing skin wound treatment.

KW - nanogenerator

KW - physical therapy

KW - self-powering

KW - wearable device

KW - wound healing

UR - http://www.scopus.com/inward/record.url?scp=85058073124&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85058073124&partnerID=8YFLogxK

U2 - 10.1021/acsnano.8b07038

DO - 10.1021/acsnano.8b07038

M3 - Article

C2 - 30488695

AN - SCOPUS:85058073124

VL - 12

SP - 12533

EP - 12540

JO - ACS Nano

JF - ACS Nano

SN - 1936-0851

IS - 12

ER -

Effective Wound Healing Enabled by Discrete Alternative Electric Fields from Wearable Nanogenerators

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this