Effectiveness of Estrogens for Therapy of Myocardial Infarction in Middle-Age Men

Jeremiah Stamler, Ruth Pick, Louis N. Katz, Alfred Pick, Benjamin M. Kaplan, David M. Berkson, Dolores Century

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


This study, begun in 1952, assessed long-term estrogen therapy in middle-aged men surviving acute myocardial infarction. By double-blind stratified randomization, 275 such men under age 50 were assigned either to a placebo-treated or to an estrogen-treated group. In the estrogen-treated group, significantly prolonged survival and decreased mortality were found in both good-risk patients and poor-risk patients. Five-year mortality rates were reduced about 50% or more by hormone treatment. However, an unexpected number of deaths occurred in the first two months of study among those men started on 10.0 mg estrogens within three months of their most recent infarction. Mixed conjugated equine estrogens seemed to be effective in the long term therapy of myocardial infarction when high initial dosage was avoided, particularly in the months immediately after infarction.

Original languageEnglish (US)
Pages (from-to)632-638
Number of pages7
JournalJAMA: The Journal of the American Medical Association
Issue number8
StatePublished - Feb 23 1963

ASJC Scopus subject areas

  • Medicine(all)


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