Effects of 17β estradiol on the metabolism of labelled arachidonic acid in uteri isolated from intact and ovariectomized rats. Influence of a restricted diet

S. M. Casalino-Matsuda, J. A. Linares, A. Goldraij*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The effects of restricted diet (50% of the normal intake during 25 days) on the metabolism of 14U arachidonic acid, were explored in uterine horn strips isolated from intact and ovariectomized rats, treated by 17 β-estradiol or controls. The metabolism of arachidonic acid into different eicosanoids, PGE2, PGF(2α), 6-keto PGF(1α) and TXB2, showed that the restricted diet diminished PGE2 and PGF(2α), in intact rats, significantly. In contrast, this kind of feeding did not produce any change in castrated rats. Tissue preparations from previously estrogenized intact and castrated normal-fed rats showed that the production of different metabolites decreased. A similar result was obtained in intact rats subjected to a restricted diet. Nevertheless, in castrated underfed rats, estrogens did not produce any effect on the various eicosanoids analysed. These results showed that in isolated uteri, the effects of 17β-estradiol, on metabolite production from labelled arachidonic acid, are different from controls in ovariectomized diet-restricted rats.

Original languageEnglish (US)
Pages (from-to)457-460
Number of pages4
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume56
Issue number6
DOIs
StatePublished - Jun 1997

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

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