TY - JOUR
T1 - Effects of a low-potency corticosteroid lotion plus a moisturizing regimen in the treatment of atopic dermatitis
AU - Hanifin, Jon M.
AU - Hebert, Adelaide A.
AU - Mays, Steven R.
AU - Paller, Amy S.
AU - Sherertz, Elizabeth F.
AU - Wagner, Annette M.
AU - Tuley, Michael R.
AU - Baker, Michael D.
N1 - Funding Information:
This study was financially supported by Galderma Laboratories Inc., Fort Worth, Texas.
PY - 1998
Y1 - 1998
N2 - Treatment goals for atopic dermatitis consist of attempting to eliminate inflammation and infection, hydrating the skin, controlling pruritus, and avoiding exacerbative factors. The aim of this study was to evaluate the effects of adding a moisturizing regimen to a low-potency topical corticosteroid lotion regimen in the treatment of atopic dermatitis. This controlled, randomized, investigator-masked 3-week study was undertaken to compare twice-daily applications of desonide lotion 0.05% alone with twice- daily applications of desonide lotion 0.05% plus three-times-daily applications of a moisturizing cream. The efficacy variables assessed included erythema, dryness or scaling, pruritus, excoriations, lichenification, oozing or crusting, and induration or papules. Administration of desonide lotion alone created statistically significant improvement in total sign and symptom scores. The addition of a moisturizer to the treatment regimen produced additional statistically significant improvement in total sign and symptom scores, physicians' global assessments of improvement, and most of the individual efficacy variables. Results of this study suggest that the addition of a moisturizer to a low-potency corticosteroid lotion in separate regimens was effective in treating the signs and symptoms of mild-to-moderate atopic dermatitis.
AB - Treatment goals for atopic dermatitis consist of attempting to eliminate inflammation and infection, hydrating the skin, controlling pruritus, and avoiding exacerbative factors. The aim of this study was to evaluate the effects of adding a moisturizing regimen to a low-potency topical corticosteroid lotion regimen in the treatment of atopic dermatitis. This controlled, randomized, investigator-masked 3-week study was undertaken to compare twice-daily applications of desonide lotion 0.05% alone with twice- daily applications of desonide lotion 0.05% plus three-times-daily applications of a moisturizing cream. The efficacy variables assessed included erythema, dryness or scaling, pruritus, excoriations, lichenification, oozing or crusting, and induration or papules. Administration of desonide lotion alone created statistically significant improvement in total sign and symptom scores. The addition of a moisturizer to the treatment regimen produced additional statistically significant improvement in total sign and symptom scores, physicians' global assessments of improvement, and most of the individual efficacy variables. Results of this study suggest that the addition of a moisturizer to a low-potency corticosteroid lotion in separate regimens was effective in treating the signs and symptoms of mild-to-moderate atopic dermatitis.
KW - Atopic dermatitis
KW - Corticosteroid lotion
KW - Low- potency steroid therapy
KW - Moisturizing regimen
UR - http://www.scopus.com/inward/record.url?scp=0031955805&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031955805&partnerID=8YFLogxK
U2 - 10.1016/S0011-393X(98)85076-5
DO - 10.1016/S0011-393X(98)85076-5
M3 - Article
AN - SCOPUS:0031955805
SN - 0011-393X
VL - 59
SP - 227
EP - 233
JO - Current Therapeutic Research
JF - Current Therapeutic Research
IS - 4
ER -