Effects of acute and chronic dexamethasone treatment on stimulated prolactin secretion in the rat

Erasmo A. Passaro*, Herbert Y. Meltzer, Gary A. Gudelsky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Basal serum concentrations of prolactin (PRL) and the elevation of serum PRL concentrations induced by the serotonergic agents, quipazine and 5-hydroxytryptophan (5-HTP) were suppressed in rats treated acutely with dexamethasone. Acute dexamethasone treatment did not alter the stimulation of PRL release produced by the dopamine antagonist haloperidol. In contrast, chronic treatment of rats with dexamethasone resulted in a potentiation of the PRL response to quipazine, 5-hydroxytryptophan and haloperidol. It is concluded that dexamethasone can exert differential effects on the secretion of PRL, and that these effects are dependent upon the duration of dexamethasone treatment.

Original languageEnglish (US)
Pages (from-to)173-182
Number of pages10
JournalEndocrine Research
Volume13
Issue number2
DOIs
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • Endocrinology

Fingerprint Dive into the research topics of 'Effects of acute and chronic dexamethasone treatment on stimulated prolactin secretion in the rat'. Together they form a unique fingerprint.

Cite this