Effects of acute and chronic dexamethasone treatment on stimulated prolactin secretion in the rat

Erasmo A. Passaro; Herbert Y. Meltzer; Gary A. Gudelsky

doi:10.3109/07435808709023671

Effects of acute and chronic dexamethasone treatment on stimulated prolactin secretion in the rat

Erasmo A. Passaro^*, Herbert Y. Meltzer, Gary A. Gudelsky

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Basal serum concentrations of prolactin (PRL) and the elevation of serum PRL concentrations induced by the serotonergic agents, quipazine and 5-hydroxytryptophan (5-HTP) were suppressed in rats treated acutely with dexamethasone. Acute dexamethasone treatment did not alter the stimulation of PRL release produced by the dopamine antagonist haloperidol. In contrast, chronic treatment of rats with dexamethasone resulted in a potentiation of the PRL response to quipazine, 5-hydroxytryptophan and haloperidol. It is concluded that dexamethasone can exert differential effects on the secretion of PRL, and that these effects are dependent upon the duration of dexamethasone treatment.

Original language	English (US)
Pages (from-to)	173-182
Number of pages	10
Journal	Endocrine Research
Volume	13
Issue number	2
DOIs	https://doi.org/10.3109/07435808709023671
State	Published - 1987

Funding

This work was supported by

ASJC Scopus subject areas

Endocrinology

Access to Document

10.3109/07435808709023671

Cite this

@article{fd4f628fc7b044118c4d096ed3d53034,

title = "Effects of acute and chronic dexamethasone treatment on stimulated prolactin secretion in the rat",

abstract = "Basal serum concentrations of prolactin (PRL) and the elevation of serum PRL concentrations induced by the serotonergic agents, quipazine and 5-hydroxytryptophan (5-HTP) were suppressed in rats treated acutely with dexamethasone. Acute dexamethasone treatment did not alter the stimulation of PRL release produced by the dopamine antagonist haloperidol. In contrast, chronic treatment of rats with dexamethasone resulted in a potentiation of the PRL response to quipazine, 5-hydroxytryptophan and haloperidol. It is concluded that dexamethasone can exert differential effects on the secretion of PRL, and that these effects are dependent upon the duration of dexamethasone treatment.",

author = "Passaro, {Erasmo A.} and Meltzer, {Herbert Y.} and Gudelsky, {Gary A.}",

year = "1987",

doi = "10.3109/07435808709023671",

language = "English (US)",

volume = "13",

pages = "173--182",

journal = "Endocrine Research",

issn = "0743-5800",

publisher = "Informa Healthcare",

number = "2",

}

TY - JOUR

T1 - Effects of acute and chronic dexamethasone treatment on stimulated prolactin secretion in the rat

AU - Passaro, Erasmo A.

AU - Meltzer, Herbert Y.

AU - Gudelsky, Gary A.

PY - 1987

Y1 - 1987

N2 - Basal serum concentrations of prolactin (PRL) and the elevation of serum PRL concentrations induced by the serotonergic agents, quipazine and 5-hydroxytryptophan (5-HTP) were suppressed in rats treated acutely with dexamethasone. Acute dexamethasone treatment did not alter the stimulation of PRL release produced by the dopamine antagonist haloperidol. In contrast, chronic treatment of rats with dexamethasone resulted in a potentiation of the PRL response to quipazine, 5-hydroxytryptophan and haloperidol. It is concluded that dexamethasone can exert differential effects on the secretion of PRL, and that these effects are dependent upon the duration of dexamethasone treatment.

AB - Basal serum concentrations of prolactin (PRL) and the elevation of serum PRL concentrations induced by the serotonergic agents, quipazine and 5-hydroxytryptophan (5-HTP) were suppressed in rats treated acutely with dexamethasone. Acute dexamethasone treatment did not alter the stimulation of PRL release produced by the dopamine antagonist haloperidol. In contrast, chronic treatment of rats with dexamethasone resulted in a potentiation of the PRL response to quipazine, 5-hydroxytryptophan and haloperidol. It is concluded that dexamethasone can exert differential effects on the secretion of PRL, and that these effects are dependent upon the duration of dexamethasone treatment.

UR - http://www.scopus.com/inward/record.url?scp=0023234073&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023234073&partnerID=8YFLogxK

U2 - 10.3109/07435808709023671

DO - 10.3109/07435808709023671

M3 - Article

C2 - 3497800

AN - SCOPUS:0023234073

SN - 0743-5800

VL - 13

SP - 173

EP - 182

JO - Endocrine Research

JF - Endocrine Research

IS - 2

ER -

Effects of acute and chronic dexamethasone treatment on stimulated prolactin secretion in the rat

Abstract

Funding

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this