Effects of amoxapine on serotonin uptake in human blood platelets of depressed patients and normal controls

Ramesh C. Arora; Herbert Y. Meltzer

doi:10.1016/0165-1781(83)90086-0

Effects of amoxapine on serotonin uptake in human blood platelets of depressed patients and normal controls

Ramesh C. Arora^*, Herbert Y. Meltzer

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The effect of amoxapine and imipramine on the serotonin (5-HT) uptake of blood platelets from depressed patients and normal controls was studied ex vivo or in vitro, respectively. Amoxapine was approximately one-tenth as potent as imipramine in inhibiting 5-HT uptake in blood platelets from normal controls in vitro. Both drugs inhibited 5-HT uptake in a competitive manner. However, ex vivo studies demonstrated that imipramine produced a mixed inhibition and amoxapine, a competitive inhibition of 5-HT uptake. There was no relationship between the change in the platelet affinity for 5-HT after treatment with amoxapine and clinical response to amoxapine.

Original language	English (US)
Pages (from-to)	29-35
Number of pages	7
Journal	Psychiatry Research
Volume	9
Issue number	1
DOIs	https://doi.org/10.1016/0165-1781(83)90086-0
State	Published - May 1983

Keywords

Amoxapine
blood platelets
depressed patients
imipramine
serotonin uptake

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/0165-1781(83)90086-0

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abstract = "The effect of amoxapine and imipramine on the serotonin (5-HT) uptake of blood platelets from depressed patients and normal controls was studied ex vivo or in vitro, respectively. Amoxapine was approximately one-tenth as potent as imipramine in inhibiting 5-HT uptake in blood platelets from normal controls in vitro. Both drugs inhibited 5-HT uptake in a competitive manner. However, ex vivo studies demonstrated that imipramine produced a mixed inhibition and amoxapine, a competitive inhibition of 5-HT uptake. There was no relationship between the change in the platelet affinity for 5-HT after treatment with amoxapine and clinical response to amoxapine.",

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AU - Meltzer, Herbert Y.

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AB - The effect of amoxapine and imipramine on the serotonin (5-HT) uptake of blood platelets from depressed patients and normal controls was studied ex vivo or in vitro, respectively. Amoxapine was approximately one-tenth as potent as imipramine in inhibiting 5-HT uptake in blood platelets from normal controls in vitro. Both drugs inhibited 5-HT uptake in a competitive manner. However, ex vivo studies demonstrated that imipramine produced a mixed inhibition and amoxapine, a competitive inhibition of 5-HT uptake. There was no relationship between the change in the platelet affinity for 5-HT after treatment with amoxapine and clinical response to amoxapine.

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Effects of amoxapine on serotonin uptake in human blood platelets of depressed patients and normal controls

Abstract

Keywords

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