Effects of amoxapine on serotonin uptake in human blood platelets of depressed patients and normal controls

Ramesh C. Arora*, Herbert Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The effect of amoxapine and imipramine on the serotonin (5-HT) uptake of blood platelets from depressed patients and normal controls was studied ex vivo or in vitro, respectively. Amoxapine was approximately one-tenth as potent as imipramine in inhibiting 5-HT uptake in blood platelets from normal controls in vitro. Both drugs inhibited 5-HT uptake in a competitive manner. However, ex vivo studies demonstrated that imipramine produced a mixed inhibition and amoxapine, a competitive inhibition of 5-HT uptake. There was no relationship between the change in the platelet affinity for 5-HT after treatment with amoxapine and clinical response to amoxapine.

Original languageEnglish (US)
Pages (from-to)29-35
Number of pages7
JournalPsychiatry Research
Volume9
Issue number1
DOIs
StatePublished - May 1983

Keywords

  • Amoxapine
  • blood platelets
  • depressed patients
  • imipramine
  • serotonin uptake

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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