Effects of anti-CD70 mAb on Theiler's murine encephalomyelitis virus-induced demyelinaiting disease

Satoshi Yanagisawa, Naoya Takeichi, Tomoki Kaneyama, Hideo Yagita, Syun'ichiro Taniguchi, Byung S. Kim, Chang Sung Koh*

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Ligation of CD27, a member of the tumor necrosis factor (TNF) receptor family, by its ligand CD70 is thought to be important in T cell activation, expansion and survival, B cell activation, and NK cell activation. We examined the role of CD70 in Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD) mice. Blocking of CD70 in effector phase by anti-CD70 monoclonal antibody (mAb) suppressed the development of TMEV-IDD. The number of IFN-γ- or TNF-α-producing cells in the spleen and mRNA levels of IFN-γ and TNF-α in spinal cord were decreased in mice treated with anti-CD70 mAb at the effector phase. In contrast, treatment with anti-CD70 mAb in induction phase failed to reduce these responses, compared to nonspecific IgG-treated control mice. These data suggest that CD70 is critically involved in the pathogenesis of TMEV-IDD and that antibodies against CD70 could be a novel therapeutic approach in the clinical treatment of demyelinating diseases such as human multiple sclerosis.

Original languageEnglish (US)
Pages (from-to)236-245
Number of pages10
JournalBrain research
Volume1317
DOIs
StatePublished - Mar 4 2010

Keywords

  • CD70
  • Costimulatory molecules
  • Demyelinating disease
  • Multiple sclerosis
  • Theiler's murine encephalomyelitis virus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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