Both the cells of monolayer culture of mouse embryonic liver and that of highly malignant hepatoma 22A transplanted for 20 yr actively metabolized the carcinogenic hydrocarbon benzo(a)pyrene and were highly sensitive to its toxic action. Since hepatic tissue was resistant in vivo to carcinogenic carbohydrates it is suggested that the resistance depended on factors acting at the organ or the organism but not at the cellular level. The mechanism of retention of hepatoma 22A sensitivity to the toxic action of benzo(a)pyrene is also discussed.
|Original language||English (US)|
|Number of pages||4|
|Journal||Bulletin of Experimental Biology and Medicine|
|State||Published - Jan 1 1978|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)