Effects of beta-adrenergic and calcium antagonists on the development of anaphylactoid reactions from radiographic contrast media during cardiac angiography

Paul Allen Greenberger*, Sheridan Norman Meyers, Barry L. Kramer, Bonnie L. Kramer

*Corresponding author for this work

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Anaphylactoid reactions (ARs) occurring in patients receiving propranolol have been described as unusually severe and having a "sluggish" response to epinephrine. Although the mechanism of ARs to iodinated radiographic contrast media is not IgE mediated, because of widespread use of β-adrenergic blocking agents, we undertook a prospective study to determine the incidence of AR to radiographic contrast media during cardiac angiography. Nine hundred fifty-two consecutive patients were divided into four groups according to concomitant chronic medications. Group I (447 patients) were receiving no β-adrenergic blocking agents or calcium antagonists. Group II (216 patients) were receiving a β-adrenergic blocking agent. Group III (147 patients) were receiving a calcium antagonist but not a β-adrenergic blocking agent. Group IV (142 patients) were receiving both a calcium antagonist and a β-adrenergic blocking agent. The reaction rates, respectively, in the four groups were 4.47%, 7.41%, 5.44%, and 4.93%. The rates of ARs were not associated with the use of concomitant medications in any of the groups (χ2 = 2.531; p = 0.47). The probability of a type II error in comparison of groups I and II was 0.75 should the true incidence of reactions in patients receiving β-adrenergic antagonists be 7.41%. No difference in the incidence of AR was observed between patients taking selective and nonselective β-adrenergic blocking agents in group II. Specific ARs occurring in patients receiving β-adrenergic blocking agents were usually mild and often without need for specific pharmacotherapy.

Original languageEnglish (US)
Pages (from-to)698-702
Number of pages5
JournalThe Journal of Allergy and Clinical Immunology
Volume80
Issue number5
DOIs
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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