Abstract
Platelet serotonin (5-HT) uptake was studied in schizophrenic patients before and after treatment with chlorpromazine (CPZ) for 2-3 weeks. No difference was noted in the affinity of 5-HT (Km) or maximum velocity of 5-HT uptake (Vmax) of unmedicated schizophrenic patients and normal controls. Administration of CPZ was associated with a significant increase in Km and Vmax. Specific uptake of 5-HT, at 0.5 μM, was significantly decreased in most subjects. Chlorpromazine inhibited 5-HT uptake into platelets from normal controls in vitro (IC50, 1.8 ± 0.1 μ M) in a competitive manner.
Original language | English (US) |
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Pages (from-to) | 23-28 |
Number of pages | 6 |
Journal | Psychiatry Research |
Volume | 9 |
Issue number | 1 |
DOIs | |
State | Published - May 1983 |
Funding
Acknowledgments. The researchr eported was supported, in part, by USPHS MH-30938, and the Department of Mental Health, State of Illinois. HYM USPHS RCSA MH-47808.
Keywords
- Chlorpromazine
- K
- and V
- platelet
- schizophrenia
- serotonin uptake
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry