Effects of chlorpromazine on serotonin uptake in blood platelets

Ramesh C. Arora*, Herbert Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Platelet serotonin (5-HT) uptake was studied in schizophrenic patients before and after treatment with chlorpromazine (CPZ) for 2-3 weeks. No difference was noted in the affinity of 5-HT (Km) or maximum velocity of 5-HT uptake (Vmax) of unmedicated schizophrenic patients and normal controls. Administration of CPZ was associated with a significant increase in Km and Vmax. Specific uptake of 5-HT, at 0.5 μM, was significantly decreased in most subjects. Chlorpromazine inhibited 5-HT uptake into platelets from normal controls in vitro (IC50, 1.8 ± 0.1 μ M) in a competitive manner.

Original languageEnglish (US)
Pages (from-to)23-28
Number of pages6
JournalPsychiatry Research
Volume9
Issue number1
DOIs
StatePublished - May 1983

Keywords

  • Chlorpromazine
  • K
  • and V
  • platelet
  • schizophrenia
  • serotonin uptake

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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