Effects of chlorpromazine on serotonin uptake in blood platelets

Ramesh C. Arora; Herbert Y. Meltzer

doi:10.1016/0165-1781(83)90085-9

Effects of chlorpromazine on serotonin uptake in blood platelets

Ramesh C. Arora^*, Herbert Y. Meltzer

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Platelet serotonin (5-HT) uptake was studied in schizophrenic patients before and after treatment with chlorpromazine (CPZ) for 2-3 weeks. No difference was noted in the affinity of 5-HT (K_m) or maximum velocity of 5-HT uptake (V_max) of unmedicated schizophrenic patients and normal controls. Administration of CPZ was associated with a significant increase in K_m and V_max. Specific uptake of 5-HT, at 0.5 μM, was significantly decreased in most subjects. Chlorpromazine inhibited 5-HT uptake into platelets from normal controls in vitro (IC₅₀, 1.8 ± 0.1 μ M) in a competitive manner.

Original language	English (US)
Pages (from-to)	23-28
Number of pages	6
Journal	Psychiatry Research
Volume	9
Issue number	1
DOIs	https://doi.org/10.1016/0165-1781(83)90085-9
State	Published - May 1983

Keywords

Chlorpromazine
K
and V
platelet
schizophrenia
serotonin uptake

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/0165-1781(83)90085-9

Cite this

@article{0a301be8cc194ffcad84eb9e3ae7dd93,

title = "Effects of chlorpromazine on serotonin uptake in blood platelets",

abstract = "Platelet serotonin (5-HT) uptake was studied in schizophrenic patients before and after treatment with chlorpromazine (CPZ) for 2-3 weeks. No difference was noted in the affinity of 5-HT (Km) or maximum velocity of 5-HT uptake (Vmax) of unmedicated schizophrenic patients and normal controls. Administration of CPZ was associated with a significant increase in Km and Vmax. Specific uptake of 5-HT, at 0.5 μM, was significantly decreased in most subjects. Chlorpromazine inhibited 5-HT uptake into platelets from normal controls in vitro (IC50, 1.8 ± 0.1 μ M) in a competitive manner.",

keywords = "Chlorpromazine, K, and V, platelet, schizophrenia, serotonin uptake",

author = "Arora, {Ramesh C.} and Meltzer, {Herbert Y.}",

note = "Funding Information: Acknowledgments. The researchr eported was supported, in part, by USPHS MH-30938, and the Department of Mental Health, State of Illinois. HYM USPHS RCSA MH-47808.",

year = "1983",

month = may,

doi = "10.1016/0165-1781(83)90085-9",

language = "English (US)",

volume = "9",

pages = "23--28",

journal = "Psychiatry Research",

issn = "0165-1781",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Effects of chlorpromazine on serotonin uptake in blood platelets

AU - Arora, Ramesh C.

AU - Meltzer, Herbert Y.

N1 - Funding Information: Acknowledgments. The researchr eported was supported, in part, by USPHS MH-30938, and the Department of Mental Health, State of Illinois. HYM USPHS RCSA MH-47808.

PY - 1983/5

Y1 - 1983/5

N2 - Platelet serotonin (5-HT) uptake was studied in schizophrenic patients before and after treatment with chlorpromazine (CPZ) for 2-3 weeks. No difference was noted in the affinity of 5-HT (Km) or maximum velocity of 5-HT uptake (Vmax) of unmedicated schizophrenic patients and normal controls. Administration of CPZ was associated with a significant increase in Km and Vmax. Specific uptake of 5-HT, at 0.5 μM, was significantly decreased in most subjects. Chlorpromazine inhibited 5-HT uptake into platelets from normal controls in vitro (IC50, 1.8 ± 0.1 μ M) in a competitive manner.

AB - Platelet serotonin (5-HT) uptake was studied in schizophrenic patients before and after treatment with chlorpromazine (CPZ) for 2-3 weeks. No difference was noted in the affinity of 5-HT (Km) or maximum velocity of 5-HT uptake (Vmax) of unmedicated schizophrenic patients and normal controls. Administration of CPZ was associated with a significant increase in Km and Vmax. Specific uptake of 5-HT, at 0.5 μM, was significantly decreased in most subjects. Chlorpromazine inhibited 5-HT uptake into platelets from normal controls in vitro (IC50, 1.8 ± 0.1 μ M) in a competitive manner.

KW - Chlorpromazine

KW - K

KW - and V

KW - platelet

KW - schizophrenia

KW - serotonin uptake

UR - http://www.scopus.com/inward/record.url?scp=0020575298&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020575298&partnerID=8YFLogxK

U2 - 10.1016/0165-1781(83)90085-9

DO - 10.1016/0165-1781(83)90085-9

M3 - Article

C2 - 6577481

AN - SCOPUS:0020575298

SN - 0165-1781

VL - 9

SP - 23

EP - 28

JO - Psychiatry Research

JF - Psychiatry Research

IS - 1

ER -

Effects of chlorpromazine on serotonin uptake in blood platelets

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this