Effects of chlorpromazine on serotonin uptake in blood platelets

Ramesh C. Arora; Herbert Y. Meltzer

doi:10.1016/0165-1781(83)90085-9

Effects of chlorpromazine on serotonin uptake in blood platelets

Ramesh C. Arora^*, Herbert Y. Meltzer

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Platelet serotonin (5-HT) uptake was studied in schizophrenic patients before and after treatment with chlorpromazine (CPZ) for 2-3 weeks. No difference was noted in the affinity of 5-HT (K_m) or maximum velocity of 5-HT uptake (V_max) of unmedicated schizophrenic patients and normal controls. Administration of CPZ was associated with a significant increase in K_m and V_max. Specific uptake of 5-HT, at 0.5 μM, was significantly decreased in most subjects. Chlorpromazine inhibited 5-HT uptake into platelets from normal controls in vitro (IC₅₀, 1.8 ± 0.1 μ M) in a competitive manner.

Original language	English (US)
Pages (from-to)	23-28
Number of pages	6
Journal	Psychiatry Research
Volume	9
Issue number	1
DOIs	https://doi.org/10.1016/0165-1781(83)90085-9
State	Published - May 1983

Funding

Acknowledgments. The researchr eported was supported, in part, by USPHS MH-30938, and the Department of Mental Health, State of Illinois. HYM USPHS RCSA MH-47808.

Keywords

Chlorpromazine
K
and V
platelet
schizophrenia
serotonin uptake

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/0165-1781(83)90085-9

Cite this

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title = "Effects of chlorpromazine on serotonin uptake in blood platelets",

abstract = "Platelet serotonin (5-HT) uptake was studied in schizophrenic patients before and after treatment with chlorpromazine (CPZ) for 2-3 weeks. No difference was noted in the affinity of 5-HT (Km) or maximum velocity of 5-HT uptake (Vmax) of unmedicated schizophrenic patients and normal controls. Administration of CPZ was associated with a significant increase in Km and Vmax. Specific uptake of 5-HT, at 0.5 μM, was significantly decreased in most subjects. Chlorpromazine inhibited 5-HT uptake into platelets from normal controls in vitro (IC50, 1.8 ± 0.1 μ M) in a competitive manner.",

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note = "Funding Information: Acknowledgments. The researchr eported was supported, in part, by USPHS MH-30938, and the Department of Mental Health, State of Illinois. HYM USPHS RCSA MH-47808.",

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AU - Meltzer, Herbert Y.

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PY - 1983/5

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N2 - Platelet serotonin (5-HT) uptake was studied in schizophrenic patients before and after treatment with chlorpromazine (CPZ) for 2-3 weeks. No difference was noted in the affinity of 5-HT (Km) or maximum velocity of 5-HT uptake (Vmax) of unmedicated schizophrenic patients and normal controls. Administration of CPZ was associated with a significant increase in Km and Vmax. Specific uptake of 5-HT, at 0.5 μM, was significantly decreased in most subjects. Chlorpromazine inhibited 5-HT uptake into platelets from normal controls in vitro (IC50, 1.8 ± 0.1 μ M) in a competitive manner.

AB - Platelet serotonin (5-HT) uptake was studied in schizophrenic patients before and after treatment with chlorpromazine (CPZ) for 2-3 weeks. No difference was noted in the affinity of 5-HT (Km) or maximum velocity of 5-HT uptake (Vmax) of unmedicated schizophrenic patients and normal controls. Administration of CPZ was associated with a significant increase in Km and Vmax. Specific uptake of 5-HT, at 0.5 μM, was significantly decreased in most subjects. Chlorpromazine inhibited 5-HT uptake into platelets from normal controls in vitro (IC50, 1.8 ± 0.1 μ M) in a competitive manner.

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Effects of chlorpromazine on serotonin uptake in blood platelets

Abstract

Funding

Keywords

ASJC Scopus subject areas

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