Effects of clozapine, olanzapine and haloperidol on ethanol-induced ascorbic acid release in mouse striatum

Yue Hou, Jing Yu Yang, Chun Fu Wu, Mei Huang

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The effects of clozapine, olanzapine and haloperidol on ethanol-induced striatal ascorbic acid (AA) release in mice were compared by using microdialysis coupled to high performance liquid chromatography with electrochemical detection. Ethanol (4.0 g/kg i.p.) significantly stimulated striatal AA release by about 200% of baseline in mice. Clozapine and olanzapine, two atypical neuroleptic drugs, at the dose of 1.0 mg/kg s.c., had no effect on basal AA or ethanol-induced AA release. However, both drugs, at the dose of 10 mg/kg s.c., significantly inhibited ethanol-induced AA release. In contrast, haloperidol, a typical neuroleptic drug, at the doses of 0.1-2.0 mg/kg, had no effect on both basal and ethanol-induced AA release. The present study demonstrated that similar actions were exhibited by clozapine and olanzapine, but not by haloperidol, for the regulation of ethanol-induced AA release in the mouse striatum.

Original languageEnglish (US)
Pages (from-to)83-89
Number of pages7
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume29
Issue number1
DOIs
StatePublished - Jan 1 2005

Keywords

  • Ascorbic acid
  • Clozapine
  • Ethanol
  • Haloperidol
  • Microdialysis
  • Olanzapine

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

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