Effects of combined administration of imipramine and chlorpromazine on β- and α2-adrenergic receptors in rat cerebral cortex

Masahiko Mikuni*, David M. Stoff, Herbert Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Administration of the combination of antidepressant and neuroleptic drugs has been reported to have a synergistic effect in the treatment of delusional depression. The effects of chronic coadministration of imipramine (IMIP) and chlorpromazine (CPZ) on β-adrenergic and α-adrenergic sites in rat cerebral cortex were studied. The combination caused the same reduction in the number of β-adrenergic receptors as IMIP alone. No changes in α-adrenergic receptors were observed with IMIP and/or CPZ.

Original languageEnglish (US)
Pages (from-to)313-316
Number of pages4
JournalEuropean Journal of Pharmacology
Volume89
Issue number3-4
DOIs
StatePublished - May 6 1983

Keywords

  • Chlorpromazine
  • Imipramine
  • Rat cerebral cortex
  • α-Adrenergic receptors
  • β-Adrenergic receptors

ASJC Scopus subject areas

  • Pharmacology

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