Abstract
Administration of the combination of antidepressant and neuroleptic drugs has been reported to have a synergistic effect in the treatment of delusional depression. The effects of chronic coadministration of imipramine (IMIP) and chlorpromazine (CPZ) on β-adrenergic and α-adrenergic sites in rat cerebral cortex were studied. The combination caused the same reduction in the number of β-adrenergic receptors as IMIP alone. No changes in α-adrenergic receptors were observed with IMIP and/or CPZ.
Original language | English (US) |
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Pages (from-to) | 313-316 |
Number of pages | 4 |
Journal | European Journal of Pharmacology |
Volume | 89 |
Issue number | 3-4 |
DOIs | |
State | Published - May 6 1983 |
Funding
Supported, in part, by USPHS MH 30059 and MH 30938. HYM is recipient of USPHS RCSA 47808.
Keywords
- Chlorpromazine
- Imipramine
- Rat cerebral cortex
- α-Adrenergic receptors
- β-Adrenergic receptors
ASJC Scopus subject areas
- Pharmacology