Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) gag CTL epitope on the course of SIVmac239 infection

Todd M. Allen; Peicheng Jing; Briana Calore; Helen Horton; David H. O'Connor; Tomas Hanke; Marian Piekarczyk; Richard Ruddersdorf; Bianca R. Mothé; Carol Emerson; Nancy Wilson; Jeffrey D. Lifson; Igor M. Belyakov; Jay A. Berzofsky; Chenxi Wang; David B. Allison; David C. Montefiori; Ronald C. Desrosiers; Steven Wolinsky; Kevin J. Kunstman; John D. Altman; Alessandro Sette; Andrew J. McMichael; David I. Watkins

doi:10.1128/JVI.76.20.10507-10511.2002

Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) gag CTL epitope on the course of SIVmac239 infection

Todd M. Allen^*, Peicheng Jing, Briana Calore, Helen Horton, David H. O'Connor, Tomas Hanke, Marian Piekarczyk, Richard Ruddersdorf, Bianca R. Mothé, Carol Emerson, Nancy Wilson, Jeffrey D. Lifson, Igor M. Belyakov, Jay A. Berzofsky, Chenxi Wang, David B. Allison, David C. Montefiori, Ronald C. Desrosiers, Steven Wolinsky, Kevin J. KunstmanJohn D. Altman, Alessandro Sette, Andrew J. McMichael, David I. Watkins

^*Corresponding author for this work

Medicine, Infectious Diseases Division

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Vaccine-induced cytotoxic T lymphocytes (CTL) have been implicated in the control of virus replication in simian immunodeficiency virus (SIV)-challenged and simian-human immunodeficiency virus-challenged macaques. Therefore, we wanted to test the impact that vaccine-induced CTL responses against an immunodominant Gag epitope might have in the absence of other immune responses. By themselves, these strong CTL responses failed to control SIVmac239 replication.

Original language	English (US)
Pages (from-to)	10507-10511
Number of pages	5
Journal	Journal of virology
Volume	76
Issue number	20
DOIs	https://doi.org/10.1128/JVI.76.20.10507-10511.2002
State	Published - Oct 2002

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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Allen, T. M., Jing, P., Calore, B., Horton, H., O'Connor, D. H., Hanke, T., Piekarczyk, M., Ruddersdorf, R., Mothé, B. R., Emerson, C., Wilson, N., Lifson, J. D., Belyakov, I. M., Berzofsky, J. A., Wang, C., Allison, D. B., Montefiori, D. C., Desrosiers, R. C., Wolinsky, S., ... Watkins, D. I. (2002). Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) gag CTL epitope on the course of SIVmac239 infection. Journal of virology, 76(20), 10507-10511. https://doi.org/10.1128/JVI.76.20.10507-10511.2002

Allen, Todd M. ; Jing, Peicheng ; Calore, Briana ; Horton, Helen ; O'Connor, David H. ; Hanke, Tomas ; Piekarczyk, Marian ; Ruddersdorf, Richard ; Mothé, Bianca R. ; Emerson, Carol ; Wilson, Nancy ; Lifson, Jeffrey D. ; Belyakov, Igor M. ; Berzofsky, Jay A. ; Wang, Chenxi ; Allison, David B. ; Montefiori, David C. ; Desrosiers, Ronald C. ; Wolinsky, Steven ; Kunstman, Kevin J. ; Altman, John D. ; Sette, Alessandro ; McMichael, Andrew J. ; Watkins, David I. / Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) gag CTL epitope on the course of SIVmac239 infection. In: Journal of virology. 2002 ; Vol. 76, No. 20. pp. 10507-10511.

@article{e8c298af5dfb4e9f8d6bd037b01be679,

title = "Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) gag CTL epitope on the course of SIVmac239 infection",

abstract = "Vaccine-induced cytotoxic T lymphocytes (CTL) have been implicated in the control of virus replication in simian immunodeficiency virus (SIV)-challenged and simian-human immunodeficiency virus-challenged macaques. Therefore, we wanted to test the impact that vaccine-induced CTL responses against an immunodominant Gag epitope might have in the absence of other immune responses. By themselves, these strong CTL responses failed to control SIVmac239 replication.",

author = "Allen, {Todd M.} and Peicheng Jing and Briana Calore and Helen Horton and O'Connor, {David H.} and Tomas Hanke and Marian Piekarczyk and Richard Ruddersdorf and Moth{\'e}, {Bianca R.} and Carol Emerson and Nancy Wilson and Lifson, {Jeffrey D.} and Belyakov, {Igor M.} and Berzofsky, {Jay A.} and Chenxi Wang and Allison, {David B.} and Montefiori, {David C.} and Desrosiers, {Ronald C.} and Steven Wolinsky and Kunstman, {Kevin J.} and Altman, {John D.} and Alessandro Sette and McMichael, {Andrew J.} and Watkins, {David I.}",

year = "2002",

month = oct,

doi = "10.1128/JVI.76.20.10507-10511.2002",

language = "English (US)",

volume = "76",

pages = "10507--10511",

journal = "Journal of Virology",

issn = "0022-538X",

publisher = "American Society for Microbiology",

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Allen, TM, Jing, P, Calore, B, Horton, H, O'Connor, DH, Hanke, T, Piekarczyk, M, Ruddersdorf, R, Mothé, BR, Emerson, C, Wilson, N, Lifson, JD, Belyakov, IM, Berzofsky, JA, Wang, C, Allison, DB, Montefiori, DC, Desrosiers, RC, Wolinsky, S, Kunstman, KJ, Altman, JD, Sette, A, McMichael, AJ & Watkins, DI 2002, 'Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) gag CTL epitope on the course of SIVmac239 infection', Journal of virology, vol. 76, no. 20, pp. 10507-10511. https://doi.org/10.1128/JVI.76.20.10507-10511.2002

Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) gag CTL epitope on the course of SIVmac239 infection. / Allen, Todd M.; Jing, Peicheng; Calore, Briana; Horton, Helen; O'Connor, David H.; Hanke, Tomas; Piekarczyk, Marian; Ruddersdorf, Richard; Mothé, Bianca R.; Emerson, Carol; Wilson, Nancy; Lifson, Jeffrey D.; Belyakov, Igor M.; Berzofsky, Jay A.; Wang, Chenxi; Allison, David B.; Montefiori, David C.; Desrosiers, Ronald C.; Wolinsky, Steven; Kunstman, Kevin J.; Altman, John D.; Sette, Alessandro; McMichael, Andrew J.; Watkins, David I.

In: Journal of virology, Vol. 76, No. 20, 10.2002, p. 10507-10511.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) gag CTL epitope on the course of SIVmac239 infection

AU - Allen, Todd M.

AU - Jing, Peicheng

AU - Calore, Briana

AU - Horton, Helen

AU - O'Connor, David H.

AU - Hanke, Tomas

AU - Piekarczyk, Marian

AU - Ruddersdorf, Richard

AU - Mothé, Bianca R.

AU - Emerson, Carol

AU - Wilson, Nancy

AU - Lifson, Jeffrey D.

AU - Belyakov, Igor M.

AU - Berzofsky, Jay A.

AU - Wang, Chenxi

AU - Allison, David B.

AU - Montefiori, David C.

AU - Desrosiers, Ronald C.

AU - Wolinsky, Steven

AU - Kunstman, Kevin J.

AU - Altman, John D.

AU - Sette, Alessandro

AU - McMichael, Andrew J.

AU - Watkins, David I.

PY - 2002/10

Y1 - 2002/10

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