Effects of dexamethasone in hypoxic-ischemic brain injury in the neonatal rat

Denis I. Altman, Richard S.K. Young*, Susan K. Yagel

*Corresponding author for this work

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

To clarify the effects of corticosteroids in neonatal hypoxic-ischemic brain injury, 7-day-old rats were subjected to unilateral common carotid artery ligation and hypoxia (Levine procedure) after being injected subculancously with saline, low-dose dexamethasone (4 mg/kg) or high-dose dexamethasone (40 mg/kg). Neither low-dose nor high-dose dexamethasone ameliorated the brain edema, lactacidemia, or hypoglycemia associated with hypoxia-ischemia. In addition, dexamethasone did not alter the pattern of neuropathology damage or reduce the fall in brain high-energy phosphates. Finally, high-dose dexamethasone-treated animals experienced significantly more mortality than did either saline-or low-dose dexamethasonc-treatcd animals. In this model of neonatal hypoxia-ischemia, dexamethasone did not confer any significant cerebral protection.

Original languageEnglish (US)
Pages (from-to)149-156
Number of pages8
JournalNeonatology
Volume46
Issue number3
DOIs
StatePublished - Jan 1 1984

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Keywords

  • Dexamethasone
  • Hypoxia-ischemia
  • Neonatal rat

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Biology

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