To clarify the effects of corticosteroids in neonatal hypoxic-ischemic brain injury, 7-day-old rats were subjected to unilateral common carotid artery ligation and hypoxia (Levine procedure) after being injected subculancously with saline, low-dose dexamethasone (4 mg/kg) or high-dose dexamethasone (40 mg/kg). Neither low-dose nor high-dose dexamethasone ameliorated the brain edema, lactacidemia, or hypoglycemia associated with hypoxia-ischemia. In addition, dexamethasone did not alter the pattern of neuropathology damage or reduce the fall in brain high-energy phosphates. Finally, high-dose dexamethasone-treated animals experienced significantly more mortality than did either saline-or low-dose dexamethasonc-treatcd animals. In this model of neonatal hypoxia-ischemia, dexamethasone did not confer any significant cerebral protection.
- Neonatal rat
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Developmental Biology