Effects of dexamethasone in hypoxic-ischemic brain injury in the neonatal rat

Denis I. Altman; Richard S.K. Young; Susan K. Yagel

doi:10.1159/000242058

Effects of dexamethasone in hypoxic-ischemic brain injury in the neonatal rat

Denis I. Altman, Richard S.K. Young^*, Susan K. Yagel

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

To clarify the effects of corticosteroids in neonatal hypoxic-ischemic brain injury, 7-day-old rats were subjected to unilateral common carotid artery ligation and hypoxia (Levine procedure) after being injected subculancously with saline, low-dose dexamethasone (4 mg/kg) or high-dose dexamethasone (40 mg/kg). Neither low-dose nor high-dose dexamethasone ameliorated the brain edema, lactacidemia, or hypoglycemia associated with hypoxia-ischemia. In addition, dexamethasone did not alter the pattern of neuropathology damage or reduce the fall in brain high-energy phosphates. Finally, high-dose dexamethasone-treated animals experienced significantly more mortality than did either saline-or low-dose dexamethasonc-treatcd animals. In this model of neonatal hypoxia-ischemia, dexamethasone did not confer any significant cerebral protection.

Original language	English (US)
Pages (from-to)	149-156
Number of pages	8
Journal	Neonatology
Volume	46
Issue number	3
DOIs	https://doi.org/10.1159/000242058
State	Published - Jan 1 1984

Keywords

Dexamethasone
Hypoxia-ischemia
Neonatal rat

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Developmental Biology

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title = "Effects of dexamethasone in hypoxic-ischemic brain injury in the neonatal rat",

abstract = "To clarify the effects of corticosteroids in neonatal hypoxic-ischemic brain injury, 7-day-old rats were subjected to unilateral common carotid artery ligation and hypoxia (Levine procedure) after being injected subculancously with saline, low-dose dexamethasone (4 mg/kg) or high-dose dexamethasone (40 mg/kg). Neither low-dose nor high-dose dexamethasone ameliorated the brain edema, lactacidemia, or hypoglycemia associated with hypoxia-ischemia. In addition, dexamethasone did not alter the pattern of neuropathology damage or reduce the fall in brain high-energy phosphates. Finally, high-dose dexamethasone-treated animals experienced significantly more mortality than did either saline-or low-dose dexamethasonc-treatcd animals. In this model of neonatal hypoxia-ischemia, dexamethasone did not confer any significant cerebral protection.",

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