Abstract
To clarify the effects of corticosteroids in neonatal hypoxic-ischemic brain injury, 7-day-old rats were subjected to unilateral common carotid artery ligation and hypoxia (Levine procedure) after being injected subculancously with saline, low-dose dexamethasone (4 mg/kg) or high-dose dexamethasone (40 mg/kg). Neither low-dose nor high-dose dexamethasone ameliorated the brain edema, lactacidemia, or hypoglycemia associated with hypoxia-ischemia. In addition, dexamethasone did not alter the pattern of neuropathology damage or reduce the fall in brain high-energy phosphates. Finally, high-dose dexamethasone-treated animals experienced significantly more mortality than did either saline-or low-dose dexamethasonc-treatcd animals. In this model of neonatal hypoxia-ischemia, dexamethasone did not confer any significant cerebral protection.
Original language | English (US) |
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Pages (from-to) | 149-156 |
Number of pages | 8 |
Journal | Neonatology |
Volume | 46 |
Issue number | 3 |
DOIs | |
State | Published - Jan 1 1984 |
Keywords
- Dexamethasone
- Hypoxia-ischemia
- Neonatal rat
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Developmental Biology