Effects of diatrizoate and iopamidol on spermatogenesis

Vahid Yaghmai, Ravi S. Harapanhalli, Yashwant D. Patel, Stephen R. Baker, Dandamudi V. Rao*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


RATIONALE AND OBJECTIVES. The biological effects of iodi-nated contrast media were examined by using spermatogenesis in mouse testis as the experimental model. METHODS. Spermhead survival and abnormality assays were used as the biological end points. Diatrizoate meglumine/ diatrizoate sodium and iopamidol were administered intravenously at equal rates and concentrations. Testicular uptake and clearance of these contrast agents were examined by high-performance liquid chromatography techniques. Appropriate mannitol solutions were employed as osmolality controls. RESULTS. Intravenous administration of the contrast agent or its respective mannitol control resulted in approximately a 30% decrease in spermhead count. A dose-related experiment with mannitol demonstrated that the spermhead count decreased rapidly until 600 mOsm/kg was reached, beyond which this decrease was minimal. Clearance of both contrast media was complete in approximately 4 hours. No significant increase in the induction of spermhead abnormalities was observed. conclusion. Osmotic substances, such as iodinated contrast agents, affect the process of spermatogenesis.

Original languageEnglish (US)
Pages (from-to)1160-1164
Number of pages5
JournalInvestigative radiology
Issue number12
StatePublished - Dec 1993


  • Adverse reactions
  • Blood-testis barrier
  • Contrast media
  • Spermatogenesis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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