TY - JOUR
T1 - Effects of diet and sexual maturation on low-density lipoprotein cholesterol during puberty
T2 - The Dietary Intervention Study in Children (DISC)
AU - Kwiterovich, Peter O.
AU - Barton, Bruce A.
AU - McMahon, Robert P.
AU - Obarzanek, Eva
AU - Hunsberger, Sally
AU - Simons-Morton, Denise
AU - Kimm, Sue Y.S.
AU - Friedman, Lisa Aronson
AU - Lasser, Norman
AU - Robson, Alan
AU - Lauer, Ronald
AU - Stevens, Victor
AU - Van Horn, Linda
AU - Gidding, Samuel
AU - Snetselaar, Linda
AU - Hartmuller, Virginia W.
AU - Greenlick, Merwyn
AU - Franklin, Frank
PY - 1997/10/21
Y1 - 1997/10/21
N2 - Background: The Dietary Intervention Study in Children (DISC) is a multicenter, randomized, controlled clinical trial designed to examine the efficacy and safety of a dietary intervention to reduce serum LDL cholesterol (LDL-C) in children with elevated LDL-C. Methods and Results: The effects of dietary intake of fat and cholesterol and of sexual maturation and body mass index (BMI) on LDL-C were examined in a 3-year longitudinal study of 663 boys and girls (age 8 to 10 years at baseline) with elevated LDL-C levels. Multiple linear regression was used to predict LDL-C at 3 years. For boys, LDL-C decreased by 0.018 mmol/L for each 10 mg/4.2 MJ decrease in dietary cholesterol (P<.05). For girls, no single nutrient was significant in the model, but a treatment group effect was evident (P<.05). In both sexes, BMI at 3 years and LDL-C at baseline were significant and positive predictors of LDL-C levels. In boys, the average LDL-C level was 0.603 mmol/L lower at Tanner stage 4+ than at Tanner stage 1 (P<.01). In girls, the average LDL-C level was 0.274 mmol/L lower at Tanner stage 4+ than at Tanner stage 1 (P<.05). Conclusions: In pubertal children, sexual maturation, BMI, dietary intervention (in girls), and dietary cholesterol (in boys) were significant in determining LDL-C. Sexual maturation was the factor associated with the greatest difference in LDL-C. Clinicians screening for dyslipidemia or following dyslipidemic children should be aware of the powerful effects of pubertal change on measurements of lipoproteins.
AB - Background: The Dietary Intervention Study in Children (DISC) is a multicenter, randomized, controlled clinical trial designed to examine the efficacy and safety of a dietary intervention to reduce serum LDL cholesterol (LDL-C) in children with elevated LDL-C. Methods and Results: The effects of dietary intake of fat and cholesterol and of sexual maturation and body mass index (BMI) on LDL-C were examined in a 3-year longitudinal study of 663 boys and girls (age 8 to 10 years at baseline) with elevated LDL-C levels. Multiple linear regression was used to predict LDL-C at 3 years. For boys, LDL-C decreased by 0.018 mmol/L for each 10 mg/4.2 MJ decrease in dietary cholesterol (P<.05). For girls, no single nutrient was significant in the model, but a treatment group effect was evident (P<.05). In both sexes, BMI at 3 years and LDL-C at baseline were significant and positive predictors of LDL-C levels. In boys, the average LDL-C level was 0.603 mmol/L lower at Tanner stage 4+ than at Tanner stage 1 (P<.01). In girls, the average LDL-C level was 0.274 mmol/L lower at Tanner stage 4+ than at Tanner stage 1 (P<.05). Conclusions: In pubertal children, sexual maturation, BMI, dietary intervention (in girls), and dietary cholesterol (in boys) were significant in determining LDL-C. Sexual maturation was the factor associated with the greatest difference in LDL-C. Clinicians screening for dyslipidemia or following dyslipidemic children should be aware of the powerful effects of pubertal change on measurements of lipoproteins.
KW - Coronary disease
KW - Diet hyperlipoproteinemia
KW - Lipoproteins
KW - Pediatrics
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U2 - 10.1161/01.CIR.96.8.2526
DO - 10.1161/01.CIR.96.8.2526
M3 - Article
C2 - 9355889
AN - SCOPUS:0343811695
SN - 0009-7322
VL - 96
SP - 2526
EP - 2533
JO - Circulation
JF - Circulation
IS - 8
ER -