TY - JOUR
T1 - Effects of Dietary Monosaccharides on Sympathetic Nervous System Activity in Adipose Tissues of Male Rats
AU - Young, James B.
AU - Weiss, Jeffrey
AU - Boufath, Nadine
PY - 2004/5
Y1 - 2004/5
N2 - Dietary carbohydrate activates the sympathetic nervous: system (SNS). As the mechanisms underlying this response are not fully characterized, studies were undertaken to compare SNS responses to ingestion of glucose, fructose, and galactose. SNS activity was examined using techniques of [ 3H]norepinephrine ([3H]NE) turnover in brown and white fat. In addition, gene expression for several sympathetically related proteins was also analyzed in these tissues. [3H]NE turnover in interscapular brown adipose tissue (IBAT) and retroperitoneal fat increased in response to glucose and fructose in the diet, whereas [3H]NE turnover in epididymal fat did not respond to either monosaccharide. Galactose feeding, by contrast, decreased [3H]NE turnover in IBAT, but increased it in epididymal, though not retroperitoneal, fat. Expression of GLUT4 was more abundant in IBAT and retroperitoneal fat from glucose- and fructose-fed animals than from diet- or galactose-fed rats. Chemical sympathectomy abolished the GLUT4 response in retroperitoneal fat, but was without effect on GLUT4 in epididymal fat. These studies are consistent with activation of a neural pathway by oral glucose or fructose, leading to SNS activation in IBAT and retroperitoneal fat and enhanced GLUT4 expression.
AB - Dietary carbohydrate activates the sympathetic nervous: system (SNS). As the mechanisms underlying this response are not fully characterized, studies were undertaken to compare SNS responses to ingestion of glucose, fructose, and galactose. SNS activity was examined using techniques of [ 3H]norepinephrine ([3H]NE) turnover in brown and white fat. In addition, gene expression for several sympathetically related proteins was also analyzed in these tissues. [3H]NE turnover in interscapular brown adipose tissue (IBAT) and retroperitoneal fat increased in response to glucose and fructose in the diet, whereas [3H]NE turnover in epididymal fat did not respond to either monosaccharide. Galactose feeding, by contrast, decreased [3H]NE turnover in IBAT, but increased it in epididymal, though not retroperitoneal, fat. Expression of GLUT4 was more abundant in IBAT and retroperitoneal fat from glucose- and fructose-fed animals than from diet- or galactose-fed rats. Chemical sympathectomy abolished the GLUT4 response in retroperitoneal fat, but was without effect on GLUT4 in epididymal fat. These studies are consistent with activation of a neural pathway by oral glucose or fructose, leading to SNS activation in IBAT and retroperitoneal fat and enhanced GLUT4 expression.
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U2 - 10.2337/diabetes.53.5.1271
DO - 10.2337/diabetes.53.5.1271
M3 - Article
C2 - 15111496
AN - SCOPUS:2342644828
VL - 53
SP - 1271
EP - 1278
JO - Diabetes
JF - Diabetes
SN - 0012-1797
IS - 5
ER -