Effects of exercise in experimental autoimmune encephalomyelitis (an animal model of multiple sclerosis)

Rachel E. Klaren, Robert W. Motl*, Jeffrey A. Woods, Stephen D. Miller

*Corresponding author for this work

Research output: Contribution to journalReview article

21 Scopus citations


Exercise training has improved many outcomes in "clinical" research involving persons with multiple sclerosis (MS), but there is limited understanding of the underlying "basic" pathophysiological mechanisms. The animal model of MS, experimental autoimmune encephalomyelitis (EAE), seems ideal for examining the effects of exercise training on MS-disease pathophysiology. EAE is an autoimmune T-helper cell-mediated disease characterized by T-cell and monocyte infiltration and inflammation in the CNS. To that end, this paper briefly describes common models of EAE, reviews existing research on exercise and EAE, and then identifies future research directions for understanding the consequences of exercise training using EAE.

Original languageEnglish (US)
Pages (from-to)14-19
Number of pages6
JournalJournal of Neuroimmunology
Issue number1-2
Publication statusPublished - Jan 1 2014



  • Exercise
  • Experimental autoimmune encephalomyelitis
  • Multiple sclerosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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