Effects of fast inward current inactivation on propagation in a two dimensional model of ventricular myocardium

N. Maglaveras*, F. J L VanCapelle, M. Allessie, A. V. Sahakian, C. Pappas, M. Strintzis

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

INa inactivation effects caused by subthreshold stimulation on longitudinal plane wavefront propagation characteristics were studied in a two-dimensional anisotropic sheet of tissue. The subthreshold stimulus was located either at the exit of a narrow isthmus, or half length constant (λx/2) away from this structural complexity. Propagation characteristics changed dramatically depending on timing of the arrival of the plane wave to the stimulated site. INa inactivation produced conduction block when located at the exit of a narrow isthmus, and propagation delays (up to 7 ms) were reduced as the stimulation point moved away from the narrow isthmus.

Original languageEnglish (US)
Title of host publicationProceedings of the Annual Conference on Engineering in Medicine and Biology
PublisherPubl by IEEE
Pages613-614
Number of pages2
Volume13
Editionpt 2
ISBN (Print)0780302168
StatePublished - Dec 1 1991
EventProceedings of the 13th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Orlando, FL, USA
Duration: Oct 31 1991Nov 3 1991

Other

OtherProceedings of the 13th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CityOrlando, FL, USA
Period10/31/9111/3/91

    Fingerprint

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Maglaveras, N., VanCapelle, F. J. L., Allessie, M., Sahakian, A. V., Pappas, C., & Strintzis, M. (1991). Effects of fast inward current inactivation on propagation in a two dimensional model of ventricular myocardium. In Proceedings of the Annual Conference on Engineering in Medicine and Biology (pt 2 ed., Vol. 13, pp. 613-614). Publ by IEEE.