Effects of fibrinogens on phase transitions in lipid model membrane systems

B. A. Cunningham, Ö Küçük*, H. C. Kwaan, M. P. Westerman, D. Tracy, L. J. Lis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


An abnormal fibrinogen that caused aggregation of red blood cells (RBC) in a patient with gangrene was examined by real-time X-ray diffraction to determine its effects on dipalmitoylphosphatidylcholine (DPPC) and 1-palmitoyl-,2-oleoylphosphatidylethanolamine (POPE) phase transitions. Similar studies were done with normal fibrinogen and results were compared. Both types of fibrinogen slightly increased the Lα → HII phase transition temperature and the HII phase parameters for POPE, while neither fibrinogen significantly affected the order-disordered acyl chain transitions in the lipid bilayer phase. However, fibrinogen differentially influenced the bilayer unit cell parameter of the gel and disordered bilayer and the gel state ripple phase. These results can be interpreted as indicating that fibrinogen has little effect on the balance of gel and disordered acyl chains in the lipid bilayer, but may influence membrane functions dependent on non-bilayer phases.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalChemistry and Physics of Lipids
Issue number1
StatePublished - Jun 24 1994


  • Fibrinogen
  • Lipid model membrane
  • Phase transitions
  • X-ray diffraction

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Cell Biology


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