TY - JOUR
T1 - Effects of hepatitis c and hiv on cognition in women
T2 - Data from the women's interagency HIV study
AU - Crystal, Howard
AU - Kleyman, Inna
AU - Anastos, Kathryn
AU - Lazar, Jason
AU - Cohen, Mardge
AU - Liu, Chenglong
AU - Pearce, Leigh
AU - Golub, Elizabeth
AU - Valcour, Victor
AU - Ho, Ann
AU - Strickler, Howard
AU - Peters, Marion
AU - Kovacs, Andrea
AU - Holman, Susan
AU - Kreek, Mary Jeanne
AU - Manly, Jennifer
PY - 2012/2/1
Y1 - 2012/2/1
N2 - Objective: To compare neuropsychological scores in women infected with HIV, women infected with both HIV and hepatitis C, and uninfected subjects. Background: Some, but not all, studies have demonstrated that dual infection with Hepatitis C virus (HCV) and HIV has worse effects on cognition than infection with HIV alone. Design/Methods: The Women's Interagency HIV Study is an ongoing prospective study of the natural history of HIV in women where participants are reevaluated every 6 months. In a crosssectional analysis, we evaluated the effects of active HIV and HCV infections on scores on symbol-digit modalities test, the Stroop interference test, and trails A and B after controlling for age, ethnicity, education, depression, liver disease, and current or past substance abuse. Results: Data were available for 1338 women-17.8 % had detectable hepatitis C virus and 67% were HIV seropositive. In fully adjusted general linear models, HCV viremia was not associated with scores on any of the cognitive tests. Conclusions: In this large sample of women, active HCV infection was not associated with scores on a small battery of neuropsychological tests.
AB - Objective: To compare neuropsychological scores in women infected with HIV, women infected with both HIV and hepatitis C, and uninfected subjects. Background: Some, but not all, studies have demonstrated that dual infection with Hepatitis C virus (HCV) and HIV has worse effects on cognition than infection with HIV alone. Design/Methods: The Women's Interagency HIV Study is an ongoing prospective study of the natural history of HIV in women where participants are reevaluated every 6 months. In a crosssectional analysis, we evaluated the effects of active HIV and HCV infections on scores on symbol-digit modalities test, the Stroop interference test, and trails A and B after controlling for age, ethnicity, education, depression, liver disease, and current or past substance abuse. Results: Data were available for 1338 women-17.8 % had detectable hepatitis C virus and 67% were HIV seropositive. In fully adjusted general linear models, HCV viremia was not associated with scores on any of the cognitive tests. Conclusions: In this large sample of women, active HCV infection was not associated with scores on a small battery of neuropsychological tests.
KW - Hepatitis C
KW - HIV
KW - Neurocognition
KW - Women
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U2 - 10.1097/QAI.0b013e318240566b
DO - 10.1097/QAI.0b013e318240566b
M3 - Article
C2 - 22107817
AN - SCOPUS:84857029882
SN - 1525-4135
VL - 59
SP - 149
EP - 154
JO - Journal of Acquired Immune Deficiency Syndromes
JF - Journal of Acquired Immune Deficiency Syndromes
IS - 2
ER -
