Effects of High-Definition and Conventional tDCS on Response Inhibition

J. Hogeveen*, Jordan Henry Grafman, M. Aboseria, A. David, M. Bikson, Katherina K. Hauner

*Corresponding author for this work

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background Response inhibition is a critical executive function, enabling the adaptive control of behavior in a changing environment. The inferior frontal cortex (IFC) is considered to be critical for response inhibition, leading researchers to develop transcranial direct current stimulation (tDCS) montages attempting to target the IFC and improve inhibitory performance. However, conventional tDCS montages produce diffuse current through the brain, making it difficult to establish causality between stimulation of any one given brain region and resulting behavioral changes. Recently, high-definition tDCS (HD-tDCS) methods have been developed to target brain regions with increased focality relative to conventional tDCS. Objective Remarkably few studies have utilized HD-tDCS to improve cognitive task performance, however, and no study has directly compared the behavioral effects of HD-tDCS to conventional tDCS. Methods In the present study, participants received either HD-tDCS or conventional tDCS to the IFC during performance of a response inhibition task (stop-signal task, SST) or a control task (choice reaction time task, CRT). A third group of participants completed the same behavioral protocols, but received tDCS to a control site (mid-occipital cortex). Post-stimulation improvement in SST performance was analyzed as a function of tDCS group and the task performed during stimulation using both conventional and Bayesian parameter estimation analyses. Results Bayesian estimation of the effects of HD- and conventional tDCS to IFC relative to control site stimulation demonstrated enhanced response inhibition for both conditions. No improvements were found after control task (CRT) training in any tDCS condition. Conclusion Results support the use of both HD- and conventional tDCS to the IFC for improving response inhibition, providing empirical evidence that HD-tDCS can be used to facilitate performance on an executive function task.

Original languageEnglish (US)
Pages (from-to)720-729
Number of pages10
JournalBrain Stimulation
Volume9
Issue number5
DOIs
StatePublished - Sep 1 2016

Fingerprint

Frontal Lobe
Executive Function
Transcranial Direct Current Stimulation
Inhibition (Psychology)
Task Performance and Analysis
Brain
Occipital Lobe
Psychological Adaptation
Causality
Reaction Time
Research Personnel

Keywords

  • Computational neurostimulation
  • HD-tDCS
  • Inferior frontal cortex
  • Response inhibition
  • Transcranial direct current stimulation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biophysics
  • Clinical Neurology

Cite this

Hogeveen, J. ; Grafman, Jordan Henry ; Aboseria, M. ; David, A. ; Bikson, M. ; Hauner, Katherina K. / Effects of High-Definition and Conventional tDCS on Response Inhibition. In: Brain Stimulation. 2016 ; Vol. 9, No. 5. pp. 720-729.
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abstract = "Background Response inhibition is a critical executive function, enabling the adaptive control of behavior in a changing environment. The inferior frontal cortex (IFC) is considered to be critical for response inhibition, leading researchers to develop transcranial direct current stimulation (tDCS) montages attempting to target the IFC and improve inhibitory performance. However, conventional tDCS montages produce diffuse current through the brain, making it difficult to establish causality between stimulation of any one given brain region and resulting behavioral changes. Recently, high-definition tDCS (HD-tDCS) methods have been developed to target brain regions with increased focality relative to conventional tDCS. Objective Remarkably few studies have utilized HD-tDCS to improve cognitive task performance, however, and no study has directly compared the behavioral effects of HD-tDCS to conventional tDCS. Methods In the present study, participants received either HD-tDCS or conventional tDCS to the IFC during performance of a response inhibition task (stop-signal task, SST) or a control task (choice reaction time task, CRT). A third group of participants completed the same behavioral protocols, but received tDCS to a control site (mid-occipital cortex). Post-stimulation improvement in SST performance was analyzed as a function of tDCS group and the task performed during stimulation using both conventional and Bayesian parameter estimation analyses. Results Bayesian estimation of the effects of HD- and conventional tDCS to IFC relative to control site stimulation demonstrated enhanced response inhibition for both conditions. No improvements were found after control task (CRT) training in any tDCS condition. Conclusion Results support the use of both HD- and conventional tDCS to the IFC for improving response inhibition, providing empirical evidence that HD-tDCS can be used to facilitate performance on an executive function task.",
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Effects of High-Definition and Conventional tDCS on Response Inhibition. / Hogeveen, J.; Grafman, Jordan Henry; Aboseria, M.; David, A.; Bikson, M.; Hauner, Katherina K.

In: Brain Stimulation, Vol. 9, No. 5, 01.09.2016, p. 720-729.

Research output: Contribution to journalArticle

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