Abstract
Background Response inhibition is a critical executive function, enabling the adaptive control of behavior in a changing environment. The inferior frontal cortex (IFC) is considered to be critical for response inhibition, leading researchers to develop transcranial direct current stimulation (tDCS) montages attempting to target the IFC and improve inhibitory performance. However, conventional tDCS montages produce diffuse current through the brain, making it difficult to establish causality between stimulation of any one given brain region and resulting behavioral changes. Recently, high-definition tDCS (HD-tDCS) methods have been developed to target brain regions with increased focality relative to conventional tDCS. Objective Remarkably few studies have utilized HD-tDCS to improve cognitive task performance, however, and no study has directly compared the behavioral effects of HD-tDCS to conventional tDCS. Methods In the present study, participants received either HD-tDCS or conventional tDCS to the IFC during performance of a response inhibition task (stop-signal task, SST) or a control task (choice reaction time task, CRT). A third group of participants completed the same behavioral protocols, but received tDCS to a control site (mid-occipital cortex). Post-stimulation improvement in SST performance was analyzed as a function of tDCS group and the task performed during stimulation using both conventional and Bayesian parameter estimation analyses. Results Bayesian estimation of the effects of HD- and conventional tDCS to IFC relative to control site stimulation demonstrated enhanced response inhibition for both conditions. No improvements were found after control task (CRT) training in any tDCS condition. Conclusion Results support the use of both HD- and conventional tDCS to the IFC for improving response inhibition, providing empirical evidence that HD-tDCS can be used to facilitate performance on an executive function task.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 720-729 |
| Number of pages | 10 |
| Journal | Brain Stimulation |
| Volume | 9 |
| Issue number | 5 |
| DOIs | |
| State | Published - Sep 1 2016 |
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Keywords
- Computational neurostimulation
- HD-tDCS
- Inferior frontal cortex
- Response inhibition
- Transcranial direct current stimulation
ASJC Scopus subject areas
- Neuroscience(all)
- Biophysics
- Clinical Neurology
Cite this
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Effects of High-Definition and Conventional tDCS on Response Inhibition. / Hogeveen, J.; Grafman, J.; Aboseria, M.; David, A.; Bikson, M.; Hauner, K. K.
In: Brain Stimulation, Vol. 9, No. 5, 01.09.2016, p. 720-729.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effects of High-Definition and Conventional tDCS on Response Inhibition
AU - Hogeveen, J.
AU - Grafman, J.
AU - Aboseria, M.
AU - David, A.
AU - Bikson, M.
AU - Hauner, K. K.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Background Response inhibition is a critical executive function, enabling the adaptive control of behavior in a changing environment. The inferior frontal cortex (IFC) is considered to be critical for response inhibition, leading researchers to develop transcranial direct current stimulation (tDCS) montages attempting to target the IFC and improve inhibitory performance. However, conventional tDCS montages produce diffuse current through the brain, making it difficult to establish causality between stimulation of any one given brain region and resulting behavioral changes. Recently, high-definition tDCS (HD-tDCS) methods have been developed to target brain regions with increased focality relative to conventional tDCS. Objective Remarkably few studies have utilized HD-tDCS to improve cognitive task performance, however, and no study has directly compared the behavioral effects of HD-tDCS to conventional tDCS. Methods In the present study, participants received either HD-tDCS or conventional tDCS to the IFC during performance of a response inhibition task (stop-signal task, SST) or a control task (choice reaction time task, CRT). A third group of participants completed the same behavioral protocols, but received tDCS to a control site (mid-occipital cortex). Post-stimulation improvement in SST performance was analyzed as a function of tDCS group and the task performed during stimulation using both conventional and Bayesian parameter estimation analyses. Results Bayesian estimation of the effects of HD- and conventional tDCS to IFC relative to control site stimulation demonstrated enhanced response inhibition for both conditions. No improvements were found after control task (CRT) training in any tDCS condition. Conclusion Results support the use of both HD- and conventional tDCS to the IFC for improving response inhibition, providing empirical evidence that HD-tDCS can be used to facilitate performance on an executive function task.
AB - Background Response inhibition is a critical executive function, enabling the adaptive control of behavior in a changing environment. The inferior frontal cortex (IFC) is considered to be critical for response inhibition, leading researchers to develop transcranial direct current stimulation (tDCS) montages attempting to target the IFC and improve inhibitory performance. However, conventional tDCS montages produce diffuse current through the brain, making it difficult to establish causality between stimulation of any one given brain region and resulting behavioral changes. Recently, high-definition tDCS (HD-tDCS) methods have been developed to target brain regions with increased focality relative to conventional tDCS. Objective Remarkably few studies have utilized HD-tDCS to improve cognitive task performance, however, and no study has directly compared the behavioral effects of HD-tDCS to conventional tDCS. Methods In the present study, participants received either HD-tDCS or conventional tDCS to the IFC during performance of a response inhibition task (stop-signal task, SST) or a control task (choice reaction time task, CRT). A third group of participants completed the same behavioral protocols, but received tDCS to a control site (mid-occipital cortex). Post-stimulation improvement in SST performance was analyzed as a function of tDCS group and the task performed during stimulation using both conventional and Bayesian parameter estimation analyses. Results Bayesian estimation of the effects of HD- and conventional tDCS to IFC relative to control site stimulation demonstrated enhanced response inhibition for both conditions. No improvements were found after control task (CRT) training in any tDCS condition. Conclusion Results support the use of both HD- and conventional tDCS to the IFC for improving response inhibition, providing empirical evidence that HD-tDCS can be used to facilitate performance on an executive function task.
KW - Computational neurostimulation
KW - HD-tDCS
KW - Inferior frontal cortex
KW - Response inhibition
KW - Transcranial direct current stimulation
UR - http://www.scopus.com/inward/record.url?scp=84966775952&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84966775952&partnerID=8YFLogxK
U2 - 10.1016/j.brs.2016.04.015
DO - 10.1016/j.brs.2016.04.015
M3 - Article
C2 - 27198577
AN - SCOPUS:84966775952
VL - 9
SP - 720
EP - 729
JO - Brain Stimulation
JF - Brain Stimulation
SN - 1935-861X
IS - 5
ER -