Effects of ipsapirone on plasma cortisol and body temperature in major depression

Herbert Y. Meltzer*, Michael Maes

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

73 Scopus citations

Abstract

Major depressed patients have been reported to exhibit significantly attenuated cortisol and hypothermic responses to ipsapirone, a serotonin (5-HT)-1A partial agonist, compared to normal controls. This study further investigated the cortisol and temperature responses to ipsapirone (0.5 mg/kg orally) and placebo in 20 normal volunteers and 12 major depressed patients. Both plasma cortisol and temperature were measured every 30 min before ipsapirone or placebo administration until 180 min post administration. Ipsapirone administration produced a significant increase in plasma cortisol levels as well as hypothermia. Major depressed patients showed significantly blunted ipsapirone-induced cortisol responses compared to normal controls. No significant differences in ipsapirone-induced hypothermic responses were found between major depressed patients and normal controls.

Original languageEnglish (US)
Pages (from-to)450-457
Number of pages8
JournalBiological psychiatry
Volume38
Issue number7
DOIs
StatePublished - Oct 1 1995

Keywords

  • 5-HT receptors
  • Depression
  • cortisol
  • hypothalamic-pituitary-adrenal axis
  • ipsapirone
  • serotonin
  • temperature

ASJC Scopus subject areas

  • Biological Psychiatry

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