Effects of lithium carbonate on serotonin uptake in rat blood platelets

Ramesh C. Arora; Richard G. Fessler; Herbert Y. Meltzer

doi:10.1016/0278-5846(83)90087-8

Effects of lithium carbonate on serotonin uptake in rat blood platelets

Ramesh C. Arora^*, Richard G. Fessler, Herbert Y. Meltzer

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

1. Lithium carbonate administration to male rats for 1 to 4 weeks increased the affinity of platelet serotonin (5-HT) uptake (decreased Km) and decreased the rate of 5-HT uptake (Vmax) when the serum lithium levels were 0.5 meq/l to 0.65 meq/l. When the serum levels were increased further to 1 meq/l, Vmax decreased further, without additional change in Km. 2. No effect on the kinetics of 5-HT uptake was observed when serum lithium levels were at 0.4 meq/l or below. 3. Addition of lithium carbonate in vitro (1 meq/l) had no effect on the Km and Vmax of rat platelet 5-HT uptake. 4. The possible mechanism of the inhibitory effect of lithium treatment on platelet 5-HT uptake is discussed.

Original language	English (US)
Pages (from-to)	39-45
Number of pages	7
Journal	Progress in Neuropsychopharmacology and Biological Psychiatry
Volume	7
Issue number	1
DOIs	https://doi.org/10.1016/0278-5846(83)90087-8
State	Published - 1983

Keywords

blood platelet
lithium
serotonin
uptake

ASJC Scopus subject areas

Pharmacology
Biological Psychiatry

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10.1016/0278-5846(83)90087-8

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@article{90218500b275456aa4368ebdb907e30e,

title = "Effects of lithium carbonate on serotonin uptake in rat blood platelets",

abstract = "1. Lithium carbonate administration to male rats for 1 to 4 weeks increased the affinity of platelet serotonin (5-HT) uptake (decreased Km) and decreased the rate of 5-HT uptake (Vmax) when the serum lithium levels were 0.5 meq/l to 0.65 meq/l. When the serum levels were increased further to 1 meq/l, Vmax decreased further, without additional change in Km. 2. No effect on the kinetics of 5-HT uptake was observed when serum lithium levels were at 0.4 meq/l or below. 3. Addition of lithium carbonate in vitro (1 meq/l) had no effect on the Km and Vmax of rat platelet 5-HT uptake. 4. The possible mechanism of the inhibitory effect of lithium treatment on platelet 5-HT uptake is discussed.",

keywords = "blood platelet, lithium, serotonin, uptake",

author = "Arora, {Ramesh C.} and Fessler, {Richard G.} and Meltzer, {Herbert Y.}",

note = "Funding Information: Supported in part by USPHS MH 30059,U SPHS MH 30938a nd by the Department of Mental Health, State of Illinois. HYM is recipient of USPHS RCSA MH 47808.",

year = "1983",

doi = "10.1016/0278-5846(83)90087-8",

language = "English (US)",

volume = "7",

pages = "39--45",

journal = "Progress in Neuropsychopharmacology and Biological Psychiatry",

issn = "0278-5846",

publisher = "Elsevier Inc.",

number = "1",

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TY - JOUR

T1 - Effects of lithium carbonate on serotonin uptake in rat blood platelets

AU - Arora, Ramesh C.

AU - Fessler, Richard G.

AU - Meltzer, Herbert Y.

N1 - Funding Information: Supported in part by USPHS MH 30059,U SPHS MH 30938a nd by the Department of Mental Health, State of Illinois. HYM is recipient of USPHS RCSA MH 47808.

PY - 1983

Y1 - 1983

N2 - 1. Lithium carbonate administration to male rats for 1 to 4 weeks increased the affinity of platelet serotonin (5-HT) uptake (decreased Km) and decreased the rate of 5-HT uptake (Vmax) when the serum lithium levels were 0.5 meq/l to 0.65 meq/l. When the serum levels were increased further to 1 meq/l, Vmax decreased further, without additional change in Km. 2. No effect on the kinetics of 5-HT uptake was observed when serum lithium levels were at 0.4 meq/l or below. 3. Addition of lithium carbonate in vitro (1 meq/l) had no effect on the Km and Vmax of rat platelet 5-HT uptake. 4. The possible mechanism of the inhibitory effect of lithium treatment on platelet 5-HT uptake is discussed.

AB - 1. Lithium carbonate administration to male rats for 1 to 4 weeks increased the affinity of platelet serotonin (5-HT) uptake (decreased Km) and decreased the rate of 5-HT uptake (Vmax) when the serum lithium levels were 0.5 meq/l to 0.65 meq/l. When the serum levels were increased further to 1 meq/l, Vmax decreased further, without additional change in Km. 2. No effect on the kinetics of 5-HT uptake was observed when serum lithium levels were at 0.4 meq/l or below. 3. Addition of lithium carbonate in vitro (1 meq/l) had no effect on the Km and Vmax of rat platelet 5-HT uptake. 4. The possible mechanism of the inhibitory effect of lithium treatment on platelet 5-HT uptake is discussed.

KW - blood platelet

KW - lithium

KW - serotonin

KW - uptake

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U2 - 10.1016/0278-5846(83)90087-8

DO - 10.1016/0278-5846(83)90087-8

M3 - Article

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AN - SCOPUS:0020965334

SN - 0278-5846

VL - 7

SP - 39

EP - 45

JO - Progress in Neuropsychopharmacology and Biological Psychiatry

JF - Progress in Neuropsychopharmacology and Biological Psychiatry

IS - 1

ER -

Effects of lithium carbonate on serotonin uptake in rat blood platelets

Abstract

Keywords

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