Effects of lithium carbonate on serotonin uptake in rat blood platelets

Ramesh C. Arora*, Richard G. Fessler, Herbert Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

1. Lithium carbonate administration to male rats for 1 to 4 weeks increased the affinity of platelet serotonin (5-HT) uptake (decreased Km) and decreased the rate of 5-HT uptake (Vmax) when the serum lithium levels were 0.5 meq/l to 0.65 meq/l. When the serum levels were increased further to 1 meq/l, Vmax decreased further, without additional change in Km. 2. No effect on the kinetics of 5-HT uptake was observed when serum lithium levels were at 0.4 meq/l or below. 3. Addition of lithium carbonate in vitro (1 meq/l) had no effect on the Km and Vmax of rat platelet 5-HT uptake. 4. The possible mechanism of the inhibitory effect of lithium treatment on platelet 5-HT uptake is discussed.

Original languageEnglish (US)
Pages (from-to)39-45
Number of pages7
JournalProgress in Neuropsychopharmacology and Biological Psychiatry
Volume7
Issue number1
DOIs
StatePublished - 1983

Keywords

  • blood platelet
  • lithium
  • serotonin
  • uptake

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

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