Effects of lithium on behaviour induced by phencyclidine and amphetamine in rats

Richard G. Fessler*, R. David Sturgeon, Scott F. London, Herbert Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

d-Amphetamine and phencyclidine (PCP) have both been reported to produce manic-like sequela in humans, effects that are reportedly antagonized by lithium. To test the hypothesis that the acute effects of these drugs in rats may serve as models of mania, the behaviors, induced by d-amphetamine (3 mg/kg) or PCP (5 mg/kg) were quantified on behavioral rating scales subsequent to chronic dietary pretreatment with lithium carbonate or control diet. On day 14 of pretreatment, PCP-induced stereotyped behaviors and ataxia were potentiated in rats receiving lithium (plasma levels 1.0±0.23 mEq/l). PCP-induced locomotor activity was not affected by lithium pretreatment. Stereotypies and locomotion induced by d-amphetamine were also not significantly affected by lithium pretreatment. These results suggest that neither PCP nor amphetamine administered acutely to rats will be useful models to explore the manic-like symptoms produced by these drugs in humans.

Original languageEnglish (US)
Pages (from-to)373-376
Number of pages4
JournalPsychopharmacology
Volume78
Issue number4
DOIs
StatePublished - Dec 1 1982

Keywords

  • Ataxia
  • Lithium
  • Locomotor activity
  • Phencyclidine
  • Rat
  • Stereotyped behaviors
  • d-amphetamine

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Effects of lithium on behaviour induced by phencyclidine and amphetamine in rats'. Together they form a unique fingerprint.

  • Cite this