Effects of midbrain, bulbar and combined morphine microinjections and systemic injections on orofacial nociception and rostral trigeminal stimulation: independent midbrain and bulbar opiate analgesia systems?

Joel P Rosenfeld*, Susan Stocco

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Microinjections of 0.35 μg and 0.7 μg morphine were made into rat nucleus reticularis paragigantocellularis and ventral central gray respectively. When injected simultaneously, the analgesic effect on orofacial thermal pain was significantly greater than the effect of either injection alone, suggesting a summation mechanism for the two sites. No microinjection affected the threshold for aversive response to main sensory trigeminal nuclear stimulation. This threshold was, however, profoundly elevated by 10 mg/kg systemic injection.

Original languageEnglish (US)
Pages (from-to)342-348
Number of pages7
JournalBrain research
Volume215
Issue number1-2
DOIs
StatePublished - Jun 29 1981

Keywords

  • opiate
  • pain
  • paragigantocellularis
  • periaqueductal gray
  • trigeminal nucleus

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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