Effects of naltrexone on mannerisms and water imbalance in polydipsic schizophrenics: a pilot study

Julia A. Becker, Morris B. Goldman*, Mohammed Y. Alam, Daniel J. Luchins

*Corresponding author for this work

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

In an open design, the opiate antagonist, naltrexone (25 mg bid), was added for six weeks to the neuroleptic regimen of seven inpatient polydipsic hyponatremic schizophrenics. Mannerisms and diurnal weight change improved slightly, the latter probably not as a consequence of diminished intake alone. Further studies are needed to clarify if stereotypies and polydipsia are modulated by endogenous opiates, and if opiate antagonists are of therapeutic value in this population.

Original languageEnglish (US)
Pages (from-to)279-282
Number of pages4
JournalSchizophrenia Research
Volume17
Issue number3
DOIs
StatePublished - Jan 1 1995

Keywords

  • (Schizophrenia)
  • Endogenous opiate
  • Hyponatremia
  • Naltrexone
  • Negative symptom
  • Polydipsia
  • Stereotypy

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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