Effects of octanoate on rat brain and liver mitochondria

W. Davis Parker, Richard Haas, David A. Stumpf*, Luis A. Eguren

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Octanoate increased state 3 and state 4 respiration in rat liver mitochondria. The respiratory control rates decreased because state 4 was disproportionately affected. The ADP:0 ratio was not affected. Octanoate produced a fall in the protonmotive force (∆p) of 30 mV during state 3 and state 4. The mitochondrial inner membrane proton conductance (Cm, h+) increased twofold during state 4. Similar effects were observed in polarographic assays of brain mitochondria, but measurements of ∆p and Cm, H+ were not possible. Octanoate produces loose coupling in isolated mitochondria. This effect may play a role in the pathogenesis of Reye’s syndrome.

Original languageEnglish (US)
Pages (from-to)1374-1377
Number of pages4
JournalNeurology
Volume33
Issue number10
DOIs
StatePublished - Oct 1983

ASJC Scopus subject areas

  • Clinical Neurology

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