Effects of ovarian steroids on glucose metabolism in uterus horns isolated from underfed rats. Influence of castration

S. M. Casalino, J. A. Linares, A. Goldraij*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The effect of a restricted diet (50% of the normal intake) during 25 days, on the glucose metabolism was explored in uterus horn strips isolated from intact and ovariectomized rats. In intact underfed rats, the formation of 14CO2 from U14C-glucose was significantly lower than in their controls. In castrated rats, the formation of 14CO2 increased after underfeeding. The return to ad libitum feeding increased glucose metabolism in both groups. Total food deprivation for 4 days diminished 14CO2 formation both in non-ovariectomized rats and in ovariectomized ones as measured at the end of this fasting period. This diminution was greater in intact rats. The increase of glucose metabolism provoked by the administration of s.c. estradiol, progesterone or their combination was more important in underfed intact animals. In intact rats, blood levels of endogenous estradiol and progesterone decreased as a result of underfeeding. In spayed ones, their low concentration increased in relation to their controls.

Original languageEnglish (US)
Pages (from-to)152-156
Number of pages5
JournalArchives of Physiology and Biochemistry
Volume104
Issue number2
DOIs
StatePublished - 1996

Keywords

  • Intact and ovariectomized rats
  • Ovarian steroids
  • Restricted diet

ASJC Scopus subject areas

  • Physiology (medical)
  • Physiology

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