Effects of papillary muscle position on in vitro dynamic strain on the porcine mitral valve

Zhaoming He, Michael S. Sacks, Lotte Baijens, Sumanas Wanant, Parina Shah, Ajit P. Yoganathan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Background and aim of the study: Improved knowledge of mitral valve (MV) mechanics is essential to understand normal MV function and design and evaluate new surgical repair procedures. Initially, the dynamic deformation of the central region of the porcine MV anterior leaflet was quantified under simulated physiological conditions to explore the effects of varying papillary muscle (PM) position. Methods: Fresh porcine MVs were mounted in an invitro physiological flow loop. The PM positions were set to normal, taut, and slack states to simulate physiological and pathological PM positions. Leaflet deformation was measured by tracking the displacement of 16 markers (∼250 μm diameter) placed in a 5 × 5 mm section of the central region of the anterior leaflet, ∼5 mm from the annulus and coaptation line. Local leaflet tissue strain and strain rates were calculated from measured displacements under dynamic loading conditions. A total of 11 mitral valves was studied. Results: Under the normal PM positional state, the average areal strain rate during valve closure was typically ∼620% per second. While not measurably altering the maximal areal strain rate, the slack PM position led to a delay in complete valve closure and more rapid leaflet loading (defined as Δ transvalvular pressure/Δ areal strain) in late systole compared to the other two PM positions. Conclusion: It was shown that PM position influenced the MV loading process in the central area of the anterior leaflet. The slack PM position led to a delay in complete valve closure and more rapid leaflet loading in late systole. This increase in loading rate may have long-term consequences in MV function.

Original languageEnglish (US)
Pages (from-to)488-494
Number of pages7
JournalJournal of Heart Valve Disease
Volume12
Issue number4
StatePublished - Jul 2003

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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