Effects of phencyclidine on [3H]catecholamine and [3H]serotonin uptake in synaptosomal preparations from rat brain

Robert C. Smith*, Herbert Y. Meltzer, Ramesh C. Arora, John M. Davis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

193 Scopus citations

Abstract

Phencyclidine inhibited uptake in vitro of [3H]norepinephrine (ic50 0.52 μM), [3H]dopamine (ic50 0.73 μM) and [3H]serotonin (ic50 0.80 μM) in crude synaptosomal preparations from rat brain through a competitive mechanism. Phencyclidine was fairly similar in potency to d-amphetamine and methylphenidate in inhibiting catecholamine uptake but was 8 times more potent than d-amphetamine and 34 times more potent than methylphenidate in inhibiting [3H]serotonin uptake.

Original languageEnglish (US)
Pages (from-to)1435-1439
Number of pages5
JournalBiochemical Pharmacology
Volume26
Issue number15
DOIs
StatePublished - Aug 1 1977

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology

Fingerprint

Dive into the research topics of 'Effects of phencyclidine on [<sup>3</sup>H]catecholamine and [<sup>3</sup>H]serotonin uptake in synaptosomal preparations from rat brain'. Together they form a unique fingerprint.

Cite this