Effects of photocoagulation on intraretinal PO2 in cat

Ewa Budzynski, Jennifer H. Smith, Paul Bryar, Gulnur Birol, Robert A. Linsenmeier

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

PURPOSE. To test the hypothesis that intraretinal PO2 increases after photocoagulation. METHODS. Anesthetized cats underwent retinal argon laser photocoagulation. At least 4 weeks after treatment, PO2-sensitive microelectrodes were used to record intraretinal PO2 profiles from healed photocoagulation lesions in anesthetized cats breathing air. Histopathologic examination of the retinas was used to confirm that the photoreceptors were destroyed and that the inner retinal layers were preserved, though somewhat disorganized, as in human panretinal photocoagulation (PRP). RESULTS. The retina and tapetum were thinner in the lesioned retina than in the nonphotocoagulated retina. Average PO2 across the inner 50% of the retina was higher (22 ± 10 mm Hg) in photocoagulated retina than in untreated retina (14 ± 7 mm Hg; P < 0.01; n = 13 cats). The minimum PO2 was also significantly higher, whereas choroidal PO2 was significantly lower in the photocoagulated retina than in untreated retina. No significant difference was found in the preretinal vitreous. After lesions, inner retinal PO2 could also be maintained above zero, even in the absence of retinal circulation. CONCLUSIONS. Previous measurements showed increased PO2 in the preretinal vitreous of rabbits and pigs (but not cats) after photocoagulation of the outer retina. These intraretinal measurements in cats provide further evidence for a chronic increase in inner retinal PO2 in lesioned areas during air breathing.

Original languageEnglish (US)
Pages (from-to)380-389
Number of pages10
JournalInvestigative Ophthalmology and Visual Science
Volume49
Issue number1
DOIs
StatePublished - Jan 2008

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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