Effects of plastic and acrylate polymers on the release profile of ambroxol hydrochloride controlled release pellets

Ishtiaq Ahmed, Monzurul Amin Roni, Golam Kibria, Muhammad Rashedul Islam*, Md Habibur Rahman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The effects of Ammonio Methacrylate copolymer dispersion (Eudragit NE 30 D) and Polyvinyl Acetate dispersion (Kollicoat® SR 30 D) are compared on the in vitro release of Ambroxol Hydrochloride from coated pellets in the current study. The nuclei pellets were manufactured by Extrusion-Spheronization with the drug, microcrystalline cellulose, lactose, maize starch, and hydroxypropyl methylcellulose followed by fluid bed coating. Dissolution study of coated pellets was performed with USP Type-II apparatus in acidic (0.1N HCl for 1 h) and buffer (phosphate buffer, pH 6.8 for 11 h) media to simulate gastrointestinal environment. The release profile of drug from two types of polymers were distinct and drug release was sustained longer by Polyvinyl Acetate film than Acrylate polymer.

Original languageEnglish (US)
Pages (from-to)181-186
Number of pages6
JournalDhaka University Journal of Pharmaceutical Sciences
Volume7
Issue number2
DOIs
StatePublished - 2008

Keywords

  • Aqueous coating
  • Eudragit® NE 30D
  • Extrusion-spheronization
  • Kollicoat® SR 30D
  • Pellets
  • Release kinetics

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology (medical)

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