Effects of plastic and acrylate polymers on the release profile of ambroxol hydrochloride controlled release pellets

Ishtiaq Ahmed; Monzurul Amin Roni; Golam Kibria; Muhammad Rashedul Islam; Md Habibur Rahman

doi:10.3329/dujps.v7i2.2176

Effects of plastic and acrylate polymers on the release profile of ambroxol hydrochloride controlled release pellets

Ishtiaq Ahmed, Monzurul Amin Roni, Golam Kibria, Muhammad Rashedul Islam^*, Md Habibur Rahman

^*Corresponding author for this work

Pharmacology

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The effects of Ammonio Methacrylate copolymer dispersion (Eudragit NE 30 D) and Polyvinyl Acetate dispersion (Kollicoat® SR 30 D) are compared on the in vitro release of Ambroxol Hydrochloride from coated pellets in the current study. The nuclei pellets were manufactured by Extrusion-Spheronization with the drug, microcrystalline cellulose, lactose, maize starch, and hydroxypropyl methylcellulose followed by fluid bed coating. Dissolution study of coated pellets was performed with USP Type-II apparatus in acidic (0.1N HCl for 1 h) and buffer (phosphate buffer, pH 6.8 for 11 h) media to simulate gastrointestinal environment. The release profile of drug from two types of polymers were distinct and drug release was sustained longer by Polyvinyl Acetate film than Acrylate polymer.

Original language	English (US)
Pages (from-to)	181-186
Number of pages	6
Journal	Dhaka University Journal of Pharmaceutical Sciences
Volume	7
Issue number	2
DOIs	https://doi.org/10.3329/dujps.v7i2.2176
State	Published - 2008

Keywords

Aqueous coating
Eudragit® NE 30D
Extrusion-spheronization
Kollicoat® SR 30D
Pellets
Release kinetics

ASJC Scopus subject areas

Pharmaceutical Science
Pharmacology (medical)

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title = "Effects of plastic and acrylate polymers on the release profile of ambroxol hydrochloride controlled release pellets",

abstract = "The effects of Ammonio Methacrylate copolymer dispersion (Eudragit NE 30 D) and Polyvinyl Acetate dispersion (Kollicoat{\textregistered} SR 30 D) are compared on the in vitro release of Ambroxol Hydrochloride from coated pellets in the current study. The nuclei pellets were manufactured by Extrusion-Spheronization with the drug, microcrystalline cellulose, lactose, maize starch, and hydroxypropyl methylcellulose followed by fluid bed coating. Dissolution study of coated pellets was performed with USP Type-II apparatus in acidic (0.1N HCl for 1 h) and buffer (phosphate buffer, pH 6.8 for 11 h) media to simulate gastrointestinal environment. The release profile of drug from two types of polymers were distinct and drug release was sustained longer by Polyvinyl Acetate film than Acrylate polymer.",

keywords = "Aqueous coating, Eudragit{\textregistered} NE 30D, Extrusion-spheronization, Kollicoat{\textregistered} SR 30D, Pellets, Release kinetics",

author = "Ishtiaq Ahmed and Roni, {Monzurul Amin} and Golam Kibria and Islam, {Muhammad Rashedul} and Rahman, {Md Habibur}",

year = "2008",

doi = "10.3329/dujps.v7i2.2176",

language = "English (US)",

volume = "7",

pages = "181--186",

journal = "Dhaka University Journal of Pharmaceutical Sciences",

issn = "1816-1820",

publisher = "University of Dhaka",

number = "2",

}

Effects of plastic and acrylate polymers on the release profile of ambroxol hydrochloride controlled release pellets. / Ahmed, Ishtiaq; Roni, Monzurul Amin; Kibria, Golam; Islam, Muhammad Rashedul; Rahman, Md Habibur.

In: Dhaka University Journal of Pharmaceutical Sciences, Vol. 7, No. 2, 2008, p. 181-186.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Effects of plastic and acrylate polymers on the release profile of ambroxol hydrochloride controlled release pellets

AU - Ahmed, Ishtiaq

AU - Roni, Monzurul Amin

AU - Kibria, Golam

AU - Islam, Muhammad Rashedul

AU - Rahman, Md Habibur

PY - 2008

Y1 - 2008

N2 - The effects of Ammonio Methacrylate copolymer dispersion (Eudragit NE 30 D) and Polyvinyl Acetate dispersion (Kollicoat® SR 30 D) are compared on the in vitro release of Ambroxol Hydrochloride from coated pellets in the current study. The nuclei pellets were manufactured by Extrusion-Spheronization with the drug, microcrystalline cellulose, lactose, maize starch, and hydroxypropyl methylcellulose followed by fluid bed coating. Dissolution study of coated pellets was performed with USP Type-II apparatus in acidic (0.1N HCl for 1 h) and buffer (phosphate buffer, pH 6.8 for 11 h) media to simulate gastrointestinal environment. The release profile of drug from two types of polymers were distinct and drug release was sustained longer by Polyvinyl Acetate film than Acrylate polymer.

AB - The effects of Ammonio Methacrylate copolymer dispersion (Eudragit NE 30 D) and Polyvinyl Acetate dispersion (Kollicoat® SR 30 D) are compared on the in vitro release of Ambroxol Hydrochloride from coated pellets in the current study. The nuclei pellets were manufactured by Extrusion-Spheronization with the drug, microcrystalline cellulose, lactose, maize starch, and hydroxypropyl methylcellulose followed by fluid bed coating. Dissolution study of coated pellets was performed with USP Type-II apparatus in acidic (0.1N HCl for 1 h) and buffer (phosphate buffer, pH 6.8 for 11 h) media to simulate gastrointestinal environment. The release profile of drug from two types of polymers were distinct and drug release was sustained longer by Polyvinyl Acetate film than Acrylate polymer.

KW - Aqueous coating

KW - Eudragit® NE 30D

KW - Extrusion-spheronization

KW - Kollicoat® SR 30D

KW - Pellets

KW - Release kinetics

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Effects of plastic and acrylate polymers on the release profile of ambroxol hydrochloride controlled release pellets

Abstract

Keywords

ASJC Scopus subject areas

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